{"id":80690,"date":"2018-03-10T00:04:27","date_gmt":"2018-03-10T00:04:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-por-los-esteroides-sexuales-de-los-mecanismos-de-transduccion-neuroendocrina-en-pinealocitos-de-rata-hembra\/"},"modified":"2018-03-10T00:04:27","modified_gmt":"2018-03-10T00:04:27","slug":"modulacion-por-los-esteroides-sexuales-de-los-mecanismos-de-transduccion-neuroendocrina-en-pinealocitos-de-rata-hembra","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-por-los-esteroides-sexuales-de-los-mecanismos-de-transduccion-neuroendocrina-en-pinealocitos-de-rata-hembra\/","title":{"rendered":"Modulacion por los esteroides sexuales de los mecanismos de transduccion neuroendocrina en pinealocitos de rata hembra."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Hernandez Diaz Francisco Javier <\/strong><\/h2>\n<p>La bios\u00edntesis de melatonina (mel) en la gl\u00e1ndula pineal se encuentra regulada mediante una v\u00eda nerviosa de naturaleza noradren\u00e9rgica que tiene su origen en la retina. La na descargada de forma masiva durante la noche interacciona con los receptores a1 y b-adren\u00e9rgicos situados en la membrana de las c\u00e9lulas pineales. La uni\u00f3n con el receptor b conduce a un incremento en el nivel intracelular de ampc por la activaci\u00f3n de la adenilato ciclasa (ac), respuesta que es potenciada por la interacci\u00f3n simult\u00e1nea de la na con el receptor a1, que activa la v\u00eda de los inositoles fosfato (ips).  el incremento en el nivel de ampc constituye la se\u00f1al que dispara la bios\u00edntesis de mel, aumentando la expresi\u00f3n y actividad de la sertonina-n-acetiltransferasa, enzima limitante en la ruta de s\u00edntesis de la hormona. Por otra parte, en animales hembra, las oscilaciones c\u00edclicas de los esteroides sexuales regulan la bios\u00edntesis de mel.  con el fin de determinar si el tal efecto subyace una modualci\u00f3n de la respuesta del pinealocito a la estimualci\u00f3n adrn\u00e9rgica, expusimos c\u00e9lulas pineales prodecentes de ratas hembra de 21 d\u00edas y ovariectomizadas, a concentraciones fisiol\u00f3gicas de estradiol (e2) y porgesterona (pg), estudiando las consecuencias de este tratamiento sobre los sistemas de transducci\u00f3n intracelular de la se\u00f1al noradren\u00e9rgica.  los resultados obtenidos muestran que una exposici\u00f3n directa a e2 redujo la bios\u00edntesis y liberaci\u00f3n de mel inducida por la estimulaci\u00f3n a1b-adren\u00e9rgica. este efecto fue debido a una inhibici\u00f3n, provocada por el estr\u00f3geno, de la acumulaci\u00f3n de ampc e ips debida a la activaci\u00f3n de los receptores by a1-adren\u00e9rgicos respectivamente.  adem\u00e1s, la exposici\u00f3n a e2 redujo el incremento en la concentraci\u00f3n intracelular de calcio ((ca+2)) producida por la estimualci\u00f3n del receptor a1 o por la despolarizaci\u00f3n con k-. La atenuaci\u00f3n de la respuesta b-adren\u00e9rgica por el e2 es compatible con un ef<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion por los esteroides sexuales de los mecanismos de transduccion neuroendocrina en pinealocitos de rata hembra.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion por los esteroides sexuales de los mecanismos de transduccion neuroendocrina en pinealocitos de rata hembra. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Hernandez Diaz Francisco Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/09\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Alonso Sol\u00eds<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Manuel mas garcia manuel <\/li>\n<li>guillermo Alvarez de toledo naranjo (vocal)<\/li>\n<li>ricardo Borges jurado (vocal)<\/li>\n<li>lucia Tabares dominguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hernandez Diaz Francisco Javier La bios\u00edntesis de melatonina (mel) en la gl\u00e1ndula pineal se encuentra regulada mediante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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