{"id":80741,"date":"2018-03-10T00:04:32","date_gmt":"2018-03-10T00:04:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-sistema-inmune-en-pacientes-alcoholicos-cronicos-expresion-de-antigenos-de-activacion-linfocitaria-y-moleculas-de-adhesion\/"},"modified":"2018-03-10T00:04:32","modified_gmt":"2018-03-10T00:04:32","slug":"el-sistema-inmune-en-pacientes-alcoholicos-cronicos-expresion-de-antigenos-de-activacion-linfocitaria-y-moleculas-de-adhesion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-sistema-inmune-en-pacientes-alcoholicos-cronicos-expresion-de-antigenos-de-activacion-linfocitaria-y-moleculas-de-adhesion\/","title":{"rendered":"El sistema inmune en pacientes alcoholicos cronicos. expresi\u00f3n de antigenos de activaci\u00f3n linfocitaria y moleculas de adhesi\u00f3n."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emilio Sacanella Meseguer <\/strong><\/h2>\n<p>Los alcoh\u00f3licos cr\u00f3nicos presentan diversas anomal\u00edas en el sistema inmune sin embargo no se sabe si ello es debido al abuso cr\u00f3nico de alcohol o la existencia de otros cofactores (malnutrici\u00f3n y\/o hepatopat\u00eda). Seleccionamos un grupo de alcoh\u00f3licos cr\u00f3nicos sin patolog\u00eda asociada y analizamos la expresi\u00f3n de ant\u00edgenos de activaci\u00f3n y mol\u00e9culas de adhesi\u00f3n en linfocitos, distribuci\u00f3n subpoblaciones linfocitarias y concentraciones de mol\u00e9culas de adhesi\u00f3n endotelial solubles y los comparamos con controles sanos no bebedores.  se obtuvieron c\u00e9lulas mononucleares de sangre perif\u00e9rica por m\u00e9todo de ficoll-hypaque, el fenotipo se realiz\u00f3 mediante inmunofluorescencia directa e indirecta, se ley\u00f3 en un citofluor\u00edmetro facscan (becton-dickinson) y el an\u00e1lisis de resultados se realiz\u00f3 co nprogramas de software espec\u00edficos (c-30 y lysis). Asimismo se obtuvo suero para las determinaciones de mol\u00e9culas de adhesi\u00f3n solubles mediante t\u00e9cnicas de elisa con kits comerciales.  se detect\u00f3 un incremento de linfocitos activados (cd25+, cd69+ y dr+) y disminuci\u00f3n de la subpoblaci\u00f3n cd19+ (linfocitos b) en alcoh\u00f3licos respecto a los controles. Asimismo los linfocitos t de los alcoh\u00f3licos expresaban en mayor cuant\u00eda mol\u00e9culas de adhesi\u00f3n de la familia de las integrinas beta 1 (cd29, vla-3,4, y 5). Por \u00faltimo se detect\u00f3 un incremento en la concentraci\u00f3n s\u00e9rica de e-selectina e icam-1 en el suero de los alcoh\u00f3licos. estos par\u00e1metros se relacionaban con el consumo de alcohol diario o acumulado. en resumen, se observa que los alcoh\u00f3licos bien nutridos y sin hepatopat\u00eda asociada presentan un estado de activaci\u00f3n linfocitaria que afecta a linfocitos t y de activaci\u00f3n entotelial y todo ello puede condicionar una respuesta inmune anormal en estos pacientes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El sistema inmune en pacientes alcoholicos cronicos. expresi\u00f3n de antigenos de activaci\u00f3n linfocitaria y moleculas de adhesi\u00f3n.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El sistema inmune en pacientes alcoholicos cronicos. expresi\u00f3n de antigenos de activaci\u00f3n linfocitaria y moleculas de adhesi\u00f3n. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emilio Sacanella Meseguer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/09\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Estruch Riba<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>Santiago Nogue xarau (vocal)<\/li>\n<li>francesc Cardellach l\u00f3pez (vocal)<\/li>\n<li>albert Par\u00e9s darnaculleta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emilio Sacanella Meseguer Los alcoh\u00f3licos cr\u00f3nicos presentan diversas anomal\u00edas en el sistema inmune sin embargo no se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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