{"id":80801,"date":"1999-01-10T00:00:00","date_gmt":"1999-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-sintetico-de-usneoidona-e-sintesis-de-un-analogo-avanzado\/"},"modified":"1999-01-10T00:00:00","modified_gmt":"1999-01-10T00:00:00","slug":"estudio-sintetico-de-usneoidona-e-sintesis-de-un-analogo-avanzado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-sintetico-de-usneoidona-e-sintesis-de-un-analogo-avanzado\/","title":{"rendered":"Estudio sintetico de usneoidona e. sintesis de un analogo avanzado."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sanchez Lopez Jos\u00e9 M. <\/strong><\/h2>\n<p>En el trabajo se plantea la s\u00edntesis total del meroditerpeno natural usneoidona e, aislado del alga parda cystoseira usneoides. Este compuesto presenta una potente actividad antiviral y antitumoral, lo que hace su s\u00edntesis total muy interesante.  la s\u00edntesis se plantea seg\u00fan dos an\u00e1lisis retrosint\u00e9ticos diferentes, que suponen en ambos casos el acoplamiento de tres fragmentos, cuya obtenci\u00f3n se realiza a partir de metilhidroquinona,  1,2:5,6-di-o-isopropiliden-d-manitol y l-linalool respectivamente.  la primera estrategia de s\u00edntesis planteada, supone la desconexi\u00f3n de los enlaces c3\u00c2\u00bf-c4\u00c2\u00bf y c8\u00c2\u00bf-c9\u00c2\u00bf, lo que da lugar a tres fragmentos de acoplamiento.  se ha realizado la s\u00edntesis de los tres fragmentos, sin embargo el fragmento central (ep\u00f3xido al\u00edlico), no experimenta reacciones de acoplamiento con el fragmento arom\u00e1tico(haluro vin\u00edlico), por lo que se sintetizan otros fragmentos intermedios modificados, que desafortunadamente sufren reacciones de apertura o eliminaci\u00f3n durante la reacci\u00f3n de acoplamiento.  la segunda estrategia de s\u00edntesis supone tambi\u00e9n tres fragmentos como consecuencia de las desconexiones de los enlaces c4\u00c2\u00bf-c5\u00c2\u00bf y c8\u00c2\u00bf-c9\u00c2\u00bf.  esta modificaci\u00f3n supone variaciones en dos de los fragmentos de acoplamiento.  se ha llevado a cabo la obtenci\u00f3n de estos dos nuevos intermedios, as\u00ed como las pertinentes modificaciones que permiten realizar reacciones de acoplamiento de forma eficaz, obteni\u00e9ndose un an\u00e1logo muy avanzado de usneoidona e, que posee todo el esqueleto carbonado presente en el producto natural, as\u00ed como la mayor parte de su funcionalidad.  una vez optimizados los rendimientos de algunos pasos de reacci\u00f3n, se habr\u00e1 establecido una ruta sint\u00e9tica eficaz para este tipo de tetrapreniltoluquinones.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio sintetico de usneoidona e. sintesis de un analogo avanzado.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio sintetico de usneoidona e. sintesis de un analogo avanzado. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sanchez Lopez Jos\u00e9 M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Gonz\u00e1lez Urones<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ines Sanchez bellido <\/li>\n<li>cesar Jimenez sanchidri\u00e1n (vocal)<\/li>\n<li>victor sotero Martin garcia (vocal)<\/li>\n<li>Jes\u00fas Trujillo vazquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sanchez Lopez Jos\u00e9 M. En el trabajo se plantea la s\u00edntesis total del meroditerpeno natural usneoidona e, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1648,17,39603,416,9386],"tags":[20976,9620,25541,1906,172785,3101],"class_list":["post-80801","post","type-post","status-publish","format-standard","hentry","category-estructura-de-moleculas-organicas","category-quimica","category-quimica-de-productos-naturales-organicos","category-quimica-organica","category-salamanca","tag-cesar-jimenez-sanchidrian","tag-ines-sanchez-bellido","tag-jesus-trujillo-vazquez","tag-julio-gonzalez-urones","tag-sanchez-lopez-jose-m","tag-victor-sotero-martin-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80801"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80801\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}