{"id":80819,"date":"1999-01-10T00:00:00","date_gmt":"1999-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/distribucion-tisular-y-subcelular-de-la-protea%c2%adna-gi2-alfa-en-el-cerebro-de-raton-adulto\/"},"modified":"1999-01-10T00:00:00","modified_gmt":"1999-01-10T00:00:00","slug":"distribucion-tisular-y-subcelular-de-la-protea%c2%adna-gi2-alfa-en-el-cerebro-de-raton-adulto","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/distribucion-tisular-y-subcelular-de-la-protea%c2%adna-gi2-alfa-en-el-cerebro-de-raton-adulto\/","title":{"rendered":"Distribuci\u00f3n tisular y subcelular de la prote\u00edna gi2 alfa en el cerebro de rat\u00f3n adulto."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Mart\u00edn Clemente <\/strong><\/h2>\n<p>El objetivo general de esta tesis ha sido identificar con precisi\u00f3n la localizaci\u00f3n tisular de la subunidad alfa de uan prote\u00edna g,la prote\u00edna gi2, en el cerebro de ratones adultos. Esta prote\u00edna g, que se ubica en el organismo, presenta altos niveles de expresi\u00f3n en el cerebro. Su nivel de expresi\u00f3n en cerebro es comparable al de la prote\u00edna m\u00e1s abundante en cerebro, a saber, la prote\u00edna go. No se ha descrito hasta ahora la distribuci\u00f3n tisular de la prote\u00edna gi2alfa en el cerebro. La disponibilidad de un anticuerpo policlonal que reconoce  de forma espec\u00edfica esta subunidad, nos permiti\u00f3 abordar el estudio de la distribuci\u00f3n anat\u00f3mica de la prote\u00edna gi2alfa en el sistema nervioso central de ratones adultos.  a partir de un estudio preliminar que nos permiti\u00f3 conocer las caracter\u00edsticas generales de la distribuci\u00f3n de la prote\u00edna en el sistema nervioso central, el trabajo se ha centrado en los siguientes objetivos generales:  el primer gran objetivo ha sido determinar si la prote\u00edna gi2alfa se expresa en cuerpos celulares y dendritas de neuronas. Los resultados priminares en este campo permitieron identificar una poblaci\u00f3n neuronal presente el septum que expresa intensamente esta prote\u00edna. En base a ello, nos hemos propuesto estudiar por medio de m\u00e9todos inmunocitoqu\u00edmicos en microscopia confocal y en microscopia electr\u00f3nica las carcter\u00edsticas fent\u00edpicas de las neuronas que expresan gi2alfa en el septum: tanto los marcadores inmunocitoqu\u00edmicos asociados, como los posibles sistemas axonales aferentes que intervanl as neuronas que expresan prote\u00edna gi2alfa.El hallazgo de la expresi\u00f3n de prote\u00edna gi2alfa en un determinado grupo de neuronas septales nos permiti\u00f3 abordar el estudio de su localizaci\u00f3n subcelular y en particular comprobar su posible localizaci\u00f3n en densidades postsin\u00e1pticas.  el segundo gran objetivo ha sido caracterizar detalladamente la fuerte expresi\u00f3n de la prote\u00edna gi2alfa en relaci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Distribuci\u00f3n tisular y subcelular de la prote\u00edna gi2 alfa en el cerebro de rat\u00f3n adulto.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Distribuci\u00f3n tisular y subcelular de la prote\u00edna gi2 alfa en el cerebro de rat\u00f3n adulto. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Mart\u00edn Clemente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Fairen Carrion<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Vidal sanz <\/li>\n<li> De felipe oroquieta Javier (vocal)<\/li>\n<li>Jos\u00e9 Manuel Garcia verdugo (vocal)<\/li>\n<li>anibal Smith fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Mart\u00edn Clemente El objetivo general de esta tesis ha sido identificar con precisi\u00f3n la localizaci\u00f3n tisular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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