{"id":80846,"date":"1999-07-10T00:00:00","date_gmt":"1999-07-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-cla%c2%adnico-epidemiologico-de-los-defectos-del-tubo-neural\/"},"modified":"1999-07-10T00:00:00","modified_gmt":"1999-07-10T00:00:00","slug":"estudio-cla%c2%adnico-epidemiologico-de-los-defectos-del-tubo-neural","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-cla%c2%adnico-epidemiologico-de-los-defectos-del-tubo-neural\/","title":{"rendered":"\u00abestudio cl\u00ednico epidemiol\u00f3gico de los defectos del tubo neural\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Desamparados Sanchis Calvo <\/strong><\/h2>\n<p>Objetivos  determinar la preValencia al nacimiento de  los defectos del tubo neural (dtn), clasificarlos seg\u00fan la teor\u00eda del cierre m\u00faltiple del turbo neural e investigar asociaciones de los distintos cierres con factores gen\u00e9ticos y ambientales.  metodos  estudio retrospectivo caso control sobre 784 dtn diagnosticados entre 1,222,698 reci\u00e9n nacidos vivos espa\u00f1oles (1-4-1976 al 31-3-1995). Se han clasificado los dtn en 6 grupos seg\u00fan los cierres afectados. Se han utilizado el or y el anova para an\u00e1lisis.  resultados  la frecuencia basal de los dtn es de 1,01 por 1000 nacimientos, observ\u00e1ndose una diminuci\u00f3n marcada de anencefalias. El 80,4% de los dtn son aislados. en su conjunto. Los dtn cumplen las caracter\u00edsticas descritas en zonas de baja preValencia. La tasa de recurrencia en hermanos es de 2,11%. El fallo del punto 4 es el que m\u00e1s recurre, afecta m\u00e1s a mujeres, se afecta m\u00e1s en s\u00edndromes g\u00e9nicos y tiene m\u00e1s abortos maternos y malformaciones familiares. El cierre 1 se afecta m\u00e1s en cormosomopat\u00edas. La exposici\u00f3n al \u00e1cido valproico produce fallo del cierre 1 y del 5 zona 1+5. La zona 2+4 y 1+5 se relaciona con m\u00e1s factores ambientales.  conclusiones  nuestra poblaci\u00f3n tiene preValencia medio baja de dtn y su dismincuci\u00f3n se debe al abortotras diagn\u00f3stico prenatal. La mitad de los dtn se producen por el fallo de 2 cierres para encontrarse. El punto 4 destaca por su realci\u00f3n con factores gen\u00e9ticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abestudio cl\u00ednico epidemiol\u00f3gico de los defectos del tubo neural\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abestudio cl\u00ednico epidemiol\u00f3gico de los defectos del tubo neural\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Desamparados Sanchis Calvo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Luisa Mart\u00ednez Fr\u00edas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Brines solanes <\/li>\n<li>elvira Rodriguez pinilla (vocal)<\/li>\n<li>enrique Gal\u00e1n g\u00f3mez (vocal)<\/li>\n<li>Luis ignacio Prieto valiente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Desamparados Sanchis Calvo Objetivos determinar la preValencia al nacimiento de los defectos del tubo neural (dtn), clasificarlos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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