{"id":80863,"date":"1999-08-10T00:00:00","date_gmt":"1999-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-y-biodisponibilidad-por-va%c2%ada-oral-de-la-cefuroxima-axetilo-en-la-rata\/"},"modified":"1999-08-10T00:00:00","modified_gmt":"1999-08-10T00:00:00","slug":"farmacocinetica-y-biodisponibilidad-por-va%c2%ada-oral-de-la-cefuroxima-axetilo-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-y-biodisponibilidad-por-va%c2%ada-oral-de-la-cefuroxima-axetilo-en-la-rata\/","title":{"rendered":"Farmacocin\u00e9tica y biodisponibilidad por v\u00edaoral de la cefuroxima axetilo en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Purificacion Ruiz Carretero <\/strong><\/h2>\n<p>La cefuroxima axetilo en un prof\u00e1rmaco aniinfeccioso de amplia difusi\u00f3n en la pr\u00e1ctica clinica. Presenta el inconveniente de su insuficiente e irregular biodisponibilidad que crea una dificultad en el establecimiento de las dosis a utilizar. Se han realizado ensayos in vivo y el ensayo corresponde a un dise\u00f1o paralelo y aleatorio distribuyendo a los animales en seis grupos. se ha administrado una dosis unica de 1.78.8.9 y 17.8 mg de cefruroxima s\u00f3dica por via intravenosa, 2.02 y 8.9 mg de cefuroxima axetilo por via oral y, 1.78 mg de cefuroxima sodica por via intraperitoneal, con el fin de detectar si existe o no efecto de primer paso hep\u00e1tico. La valoraci\u00f3n de la cefuroxima en las muestras plasm\u00e1ticas se ha realizado mediante cromatografia liquida de alta eficacia, hplc. El m\u00e9todo se ha validado en cuanto a exactitud y precisi\u00f3n. A partir de los datos de concentraci\u00f3n plasm\u00e1tica y tiempos de toma de muestra se ha realizado una an\u00e1lisis compartimental, un an\u00e1lisis no compartimental y, por \u00faltimo, un an\u00e1lisis poblacional mediante el m\u00e9todo promedio simple de datos. Adicionalmente, se ha estimado la biodisponibilidad en magnitud y velocidad de la cefuroxima axetilo administrada por las v\u00edas oral e intraperitoneal. Con los resultados obtenidos, se llega a la conclusion de que la biodisponibilidad por v\u00eda oral no se modifica con la dosis, pero si la biodisponibilidad por via oral no se modifica con la dosis, pero si la biodisponibilidad en la velocidad, ya que la constante de absorci\u00f3n disminuye al aumentar la dosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica y biodisponibilidad por v\u00edaoral de la cefuroxima axetilo en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica y biodisponibilidad por v\u00edaoral de la cefuroxima axetilo en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Purificacion Ruiz Carretero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente German Casabo Alos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Pla delfina  Jos\u00e9 m <\/li>\n<li>irene Molina Martinez (vocal)<\/li>\n<li>martin Aldasoro celaya (vocal)<\/li>\n<li>pilar Igartua ayerra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Purificacion Ruiz Carretero La cefuroxima axetilo en un prof\u00e1rmaco aniinfeccioso de amplia difusi\u00f3n en la pr\u00e1ctica clinica. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189],"tags":[17650,94817,172878,11483,82615,12342],"class_list":["post-80863","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","tag-irene-molina-Martinez","tag-martin-aldasoro-celaya","tag-pilar-igartua-ayerra","tag-pla-delfina-jose-m","tag-purificacion-ruiz-carretero","tag-vicente-german-casabo-alos"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80863"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80863\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}