{"id":80878,"date":"1999-09-10T00:00:00","date_gmt":"1999-09-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-suspensiones-de-liberacion-controlada-y-formas-bioadhesivas-a-partir-de-complejos-ionicos-microencapsulados-con-polimeros-acrilicos\/"},"modified":"1999-09-10T00:00:00","modified_gmt":"1999-09-10T00:00:00","slug":"desarrollo-de-suspensiones-de-liberacion-controlada-y-formas-bioadhesivas-a-partir-de-complejos-ionicos-microencapsulados-con-polimeros-acrilicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-suspensiones-de-liberacion-controlada-y-formas-bioadhesivas-a-partir-de-complejos-ionicos-microencapsulados-con-polimeros-acrilicos\/","title":{"rendered":"Desarrollo de suspensiones de liberacion controlada y formas  bioadhesivas a partir de complejos ionicos microencapsulados con  polimeros acrilicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Margarita M. Cu\u00f1a Vilan <\/strong><\/h2>\n<p>Esta memoria experimental se ha basado en el desarrollo de suspensiones de liberaci\u00f3n controlada y formas de residencia g\u00e1strica prolongada a partir de complejos i\u00f3nicos microencapsulados con pol\u00edmeros acr\u00edlicos.  en la primera parte el objetivo se centr\u00f3 en el estudio de suspensiones de liberaci\u00f3n controlada de terbutalina, obtenidas a partir de complejos i\u00f3nicos microencapsulados con mezclas de dos pol\u00edmeros acr\u00edlicos insolubles en agua, eudragit  rs y ri. Se utilizaron dos procedimientos de microencapsulaci\u00f3n, evaporaci\u00f3n del disolvente en fase externa oleosa y en fase externa acuosa. En ambos casos, se prepararon microc\u00e1psulas con un adecuado control de la liberaci\u00f3n del principio activo, en funci\u00f3n de la composici\u00f3n de la cubierta polim\u00e9rica. El estudio de estabilidad de las microc\u00e1psulas en suspensi\u00f3n acuosa puso de manifiesto diferencias entre las dos formulaciones. Las microc\u00e1psulas elaboradas en medio anhidro se rompieron a partir del primer d\u00eda de almacenamiento, debido al hinchamiento de las part\u00edculas de resinas al ponerse en contacto con un medio acuoso. sin embargo, las microc\u00e1psulas elaboradas por el m\u00e9todo de fase externa acuosa mantuvieron su integridad y el control de liberaci\u00f3n del principio activo durante los seis meses del estudio de estabilidad.  la segunda parte del trabajo se bas\u00f3 en el desarrollo de formas de residencia g\u00e1strica prolongada de amoxicilina, a partir de complejos i\u00f3nicos microencapsulados con dos pol\u00edmeros acr\u00edlicos bioadhesivos, polycarbophil y carbopol 934. Con estos sistemas se pretend\u00eda prolongar el ya elevado tiempo de residencia g\u00e1strica de las resinas, para lograr una acci\u00f3n local en el est\u00f3mago del antibi\u00f3tico frente al microorganismo helicobacter pylori. El m\u00e9todo de microencapsulaci\u00f3n utilizado fue el de evaporaci\u00f3n del disolvente en fase externa oleosa. una vez preparadas las micropart\u00edculas, se evalu\u00f3 su comportamiento in vivo median<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de suspensiones de liberacion controlada y formas  bioadhesivas a partir de complejos ionicos microencapsulados con  polimeros acrilicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de suspensiones de liberacion controlada y formas  bioadhesivas a partir de complejos ionicos microencapsulados con  polimeros acrilicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Margarita M. Cu\u00f1a Vilan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Dolores Torres L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Vila jato <\/li>\n<li>Juan  Manuel Irache garreta (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Alonso fernandez (vocal)<\/li>\n<li>Mar\u00eda  rosa Jimenez castellanos ballesteros (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Margarita M. Cu\u00f1a Vilan Esta memoria experimental se ha basado en el desarrollo de suspensiones de liberaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,3304,977],"tags":[3220,43303,172900,67569,52382,3013],"class_list":["post-80878","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-preparacion-de-farmacos","category-santiago-de-compostela","tag-jose-luis-vila-jato","tag-juan-manuel-irache-garreta","tag-margarita-m-cuna-vilan","tag-maria-dolores-torres-lopez","tag-maria-jose-alonso-fernandez","tag-maria-rosa-jimenez-castellanos-ballesteros"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80878"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80878\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}