{"id":80884,"date":"2018-03-10T00:04:40","date_gmt":"2018-03-10T00:04:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-galenico-preformulacion-y-formulacion-de-microesferas-del-antineoplasico-bcnu-para-implantacion-intracraneal\/"},"modified":"2018-03-10T00:04:40","modified_gmt":"2018-03-10T00:04:40","slug":"desarrollo-galenico-preformulacion-y-formulacion-de-microesferas-del-antineoplasico-bcnu-para-implantacion-intracraneal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-galenico-preformulacion-y-formulacion-de-microesferas-del-antineoplasico-bcnu-para-implantacion-intracraneal\/","title":{"rendered":"Desarrollo gal\u00e9nico (preformulaci\u00f3n y formulaci\u00f3n) de microesferas del antineopl\u00e1sico bcnu para implantaci\u00f3n intracraneal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ver\u00f3nica Ruz Palomar <\/strong><\/h2>\n<p>El objetivo del presente trabajo es desarrollar microesferas biodegradables cargadas de bcnu (agente anineopl\u00e1sico) que liberen el principio activo de forma sostenida en el tiempo. Estas microesferas se administrar\u00e1n intracranealmente en las zonas adyacentes al tumor, tras su extirpaci\u00f3n quir\u00fargica con el fin de evitar recidivas.  -la formulaci\u00f3n del bcnu en microesferas de administraci\u00f3n intracraneal evitar\u00eda su distribuci\u00f3n sistem\u00e1tica,y por lo tanto, minimizar\u00eda su toxicidad.  -la cesi\u00f3n sostenida del bcnu a partir de las microesferas proporcionar\u00eda elevada concentraciones locales del citost\u00e1tico durante un prolongado periodo de tiempo.  para ello, se define y pone a punto un m\u00e9todo para el an\u00e1lisis cuantitativo de bcnu incorporado en microesferas de plg, basado en cromatografia l\u00edquida de alta eficacia. Se elaboran y caracterizan microesferas de bcnu, mediante la t\u00e9cnica de evaporaci\u00f3n-extracci\u00f3n de solventes basado en la formaci\u00f3n de emulsiones o\/a y no acuosas. Los valores mayores de eficacia de encapsulaci\u00f3n se obtienen mediante formaci\u00f3n de emulsiones o\/a(59%) frente al 20% conseguido mediante formaci\u00f3n de emulsiones no acuosas. En las microesferas seleccionadas(obtenidas por formaci\u00f3n de emulsiones o\/a) el bcnu se encuentra disperso en el seno del material polim\u00e9rico al estado particular. Se llevan cabo los consiguientes estudios de cesi\u00f3n y estabilidad del bcnu en las microesferas: la cesi\u00f3n del bcnu a partir de las microesferas se produce durante 10 d\u00edas, adem\u00e1s el bcnu incorporado en las microesferas almacenadas en recipiente herm\u00e9tico, a 4\u00c2\u00ba c, y protegido de la luz es inestable. El periodo de validez estimado, en estas condiciones, es de diez meses y medio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo gal\u00e9nico (preformulaci\u00f3n y formulaci\u00f3n) de microesferas del antineopl\u00e1sico bcnu para implantaci\u00f3n intracraneal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo gal\u00e9nico (preformulaci\u00f3n y formulaci\u00f3n) de microesferas del antineopl\u00e1sico bcnu para implantaci\u00f3n intracraneal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ver\u00f3nica Ruz Palomar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Antonia Camacho S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>rosa Mar\u00eda Hernandez martin (vocal)<\/li>\n<li> Jimenez castellanos M\u00aa rosa (vocal)<\/li>\n<li>carmen Mar\u00eda Evora Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ver\u00f3nica Ruz Palomar El objetivo del presente trabajo es desarrollar microesferas biodegradables cargadas de bcnu (agente anineopl\u00e1sico) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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