{"id":80915,"date":"2018-03-10T00:04:44","date_gmt":"2018-03-10T00:04:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-farmacologica-de-las-neuronas-serotonergicas-del-nucleo-dorsal-del-rafe-en-la-rata-nuevas-evidencias-funcionales\/"},"modified":"2018-03-10T00:04:44","modified_gmt":"2018-03-10T00:04:44","slug":"modulacion-farmacologica-de-las-neuronas-serotonergicas-del-nucleo-dorsal-del-rafe-en-la-rata-nuevas-evidencias-funcionales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-farmacologica-de-las-neuronas-serotonergicas-del-nucleo-dorsal-del-rafe-en-la-rata-nuevas-evidencias-funcionales\/","title":{"rendered":"Modulacion farmacologica de las neuronas seroton\u00e9rgicas del nucleo dorsal del rafe en la rata. nuevas evidencias funcionales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raul Martin Ruiz <\/strong><\/h2>\n<p>El nucleo dorsal del rafe(ndr) es el principal n\u00facleo seroton\u00e9rgico del cerebro de los mam\u00edferos. Su actividad est\u00e1 controlada de manera intr\u00ednseca por mecanismos i\u00f3nicos y receptores del subtipo 5-ht1a y de manera extr\u00ednseca por proyecciones procedente de numerosos n\u00facleos cerebrales y por la activaci\u00f3n de distintos receptores localizados en el propio ndr. El objetivo de estudio de esta tesis doctoral fue determinar la influencia de algunos mecanismos extrnsecos poco estudiados en el control de la actividad del ndr mediante electrofisiolog\u00eda en rata anestesiada y microdi\u00e1lisis intracerebral en rata consciente. As\u00ed, estudiamos la influencia del sistema dopamin\u00e9rgico-principalmente de la activaci\u00f3n del receptor d2- en la actividad del ndr y la posibilidad de que los receptores implicados estuvieran en la sustancia negra(sn). tambi\u00e9n estudiamos la posible implicaci\u00f3n de receptores 5-ht1a postsin\u00e1pticos sobre el control de la actividad de las neuronas seroton\u00e9rgicas del ndr. por \u00faltimo estudiamos la eventual relevancia funcional de los receptores para imidazolinas del tipo i2 presentes en el ndr. Los resultados obtenidos confirman la existencia de un control dopamin\u00e9rgico sobre la actividad de las neuronas soroton\u00e9rgicas del ndr mediada principalmente por el receptor d2. Tambi\u00e9n confirman la existencia de un control sobre dichas neuronas mediado por receptores 5-ht1a localizados en neuronas postsin\u00e1pticas al ndr. Por \u00faltimo, los efectos observados tras la administraci\u00f3n de un f\u00e1rmaco con actividad sobre los receptores, sino a una inhibici\u00f3n de la recaptaci\u00f3n de la serotonina por parte de dicho f\u00e1rmaco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion farmacologica de las neuronas seroton\u00e9rgicas del nucleo dorsal del rafe en la rata. nuevas evidencias funcionales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion farmacologica de las neuronas seroton\u00e9rgicas del nucleo dorsal del rafe en la rata. nuevas evidencias funcionales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raul Martin Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luisa Ugedo Urruela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Del rio zambrano joaquin <\/li>\n<li>angel Pazo carro (vocal)<\/li>\n<li>isabel Ulibarri marcos (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raul Martin Ruiz El nucleo dorsal del rafe(ndr) es el principal n\u00facleo seroton\u00e9rgico del cerebro de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,6530,183,12909],"tags":[172957,106550,23854,13466,172956],"class_list":["post-80915","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacologia-experimental","category-farmacos-psicotropicos","category-pais-vasco-euskal-herriko-unibertsitatea","tag-angel-pazo-carro","tag-del-rio-zambrano-joaquin","tag-isabel-ulibarri-marcos","tag-luisa-ugedo-urruela","tag-raul-martin-ruiz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80915"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80915\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}