{"id":80936,"date":"2018-03-10T00:04:44","date_gmt":"2018-03-10T00:04:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-metabolica-de-isoenciales-de-cys450-humano-in-vitro\/"},"modified":"2018-03-10T00:04:44","modified_gmt":"2018-03-10T00:04:44","slug":"estudio-de-la-actividad-metabolica-de-isoenciales-de-cys450-humano-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-actividad-metabolica-de-isoenciales-de-cys450-humano-in-vitro\/","title":{"rendered":"Estudio de la actividad metab\u00f3lica de isoenciales de cys450 humano in vitro"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guillermo Gervasini Rodriguez <\/strong><\/h2>\n<p>Dado que est\u00e1 demostrada la presencia de varias formas del citocromo p450 en el sistema nervioso central , y teniendo en cuenta que la existencia de sustratos end\u00f3genos para el cyp450 no est\u00e1 suficientemente esclarecida se estableci\u00f3n como objetivo de este trabajo el estudiar la relaci\u00f3n existente entre la actividad de tres isoenzimas de este citocromo (cyp2c9,cyp3a y cyp1a2)y el metabolismo de aminas cerebrales.  se estudio la modulaci\u00f3n de la actividad de las tres enzimas estudiadas por parte de diversos neurotransmisores y sustancias relacionadas , se identificaron las sustancias capaces de inhibir la actividad enzim\u00e1tica y se determin\u00f3 el tipo de inhibici\u00f3n producida.Una vez identetificados los potenciales candidatos a sustrato de la enzima en cuesti\u00f3n se estudi\u00f3 su posible biotransformaci\u00f3n por la enzima inhibida.  de las sustancias end\u00f3genas ensayadas triptamina,dopamina, tirosina, triptofol y adrenalina inhibieron la actividad cyp1a2 en microsomas hep\u00e1ticos humanos, secrotonina y triptamina de forma competitava.Asimismo, adrenalnalina y sorotonina inhibieron la actividad cyp2c9 y,por \u00faltimo, serotonina, 5-hidroxiptofol y adrenalina inhibieron la actividad cyp3a,haci\u00e9ndolo serotonina de forma competitiva.  la inhibici\u00f3n de estos neurotransmisores y sus precursores y metabolitos sobre diferentes isoenzimas cyp450 no es artefacto producido por la inhibici\u00f3n de la actividad nadph reductasa aparejad al citocromo p450.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la actividad metab\u00f3lica de isoenciales de cys450 humano in vitro<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la actividad metab\u00f3lica de isoenciales de cys450 humano in vitro <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guillermo Gervasini Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Benitez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Serrano molina Jos\u00e9 s. <\/li>\n<li>Javier Mi\u00f1ado s\u00e1nchez (vocal)<\/li>\n<li>Jos\u00e9 augusto Garc\u00eda-ag\u00fandez p\u00e9rez-coca (vocal)<\/li>\n<li>m.teresa Blanco roca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guillermo Gervasini Rodriguez Dado que est\u00e1 demostrada la presencia de varias formas del citocromo p450 en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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