{"id":80954,"date":"2018-03-10T00:04:44","date_gmt":"2018-03-10T00:04:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interaccion-valproato-ciclo-de-la-metionina-en-la-administracion-aguda-y-prolongada-del-farmaco-mecanismos-implicados\/"},"modified":"2018-03-10T00:04:44","modified_gmt":"2018-03-10T00:04:44","slug":"estudio-de-la-interaccion-valproato-ciclo-de-la-metionina-en-la-administracion-aguda-y-prolongada-del-farmaco-mecanismos-implicados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-interaccion-valproato-ciclo-de-la-metionina-en-la-administracion-aguda-y-prolongada-del-farmaco-mecanismos-implicados\/","title":{"rendered":"Estudio de la interacci\u00f3n valproato-ciclo de la metionina en la administraci\u00f3n aguda y prolongada del f\u00e1rmaco: mecanismos implicados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Natalia \u00fabeda Mart\u00edn <\/strong><\/h2>\n<p>Hemos evaluado la interacci\u00f3n del valproato, f\u00e1rmaco antiepil\u00e9ptico e inductor de teratog\u00e9nesis durante la gestaci\u00f3n,con el ciclo de la metionina. en primer lugar, comparamos la administraci\u00f3n diaria de valproato en rata por tres v\u00edas distintas. La v\u00eda de elecci\u00f3n fue la inyecci\u00f3n subcut\u00e1nea debido a  que no modifica el crecimiento de los animales y proporciona concentraciones s\u00e9ricas del f\u00e1rmaco elevadas. En segundo lugar, estudiamos las alteraciones inducidas por la administraci\u00f3n aguda de valporato sobre distintos marcadores del ciclo de la metionina. El valproato disminuye significativamente la actividad enzim\u00e1tica metionina adenosiltransferesa y las concentraciondes de vitaminas b6 y b12, y aumenta la concentraci\u00f3n hep\u00e1tica de s-adenosilhomociste\u00edna. En tercer lugar, estudiamos las alteraciones metab\u00f3licas sobre el ciclo de la metionina inducidas porla adminsitraci\u00f3n prolongda de valproato en gestaci\u00f3n y en situaci\u00f3n fisiol\u00f3gica normal, y las alteraciones morfol\u00f3gicas en los fetos. Tambi\u00e9n ensayamos la administraci\u00f3n ex\u00f3gena de s-adenosilmetionina, como posible agente protector de estas alteraciones. El valproato disminuye el peso y el tama\u00f1o fetal e induce a malformaciones \u00f3eseas, sin embargo no influjo alteraciones en el ciclo de la metionina, cuando los par\u00e1metros fueron determinados veinticuatro horas de la adminsitraci\u00f3n del f\u00e1rmaco. La s-adenosilmetionina no protegi\u00f3 de los efectos adversos del valproato.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interacci\u00f3n valproato-ciclo de la metionina en la administraci\u00f3n aguda y prolongada del f\u00e1rmaco: mecanismos implicados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interacci\u00f3n valproato-ciclo de la metionina en la administraci\u00f3n aguda y prolongada del f\u00e1rmaco: mecanismos implicados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Natalia \u00fabeda Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 San pablo-ceu<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gregorio Varela Moreiras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emilio Herrera castillon <\/li>\n<li>Jos\u00e9 Mar\u00eda Mato de la paz (vocal)<\/li>\n<li>Jos\u00e9 alfredo Martinez hernandez (vocal)<\/li>\n<li>olimpia Carreras s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Natalia \u00fabeda Mart\u00edn Hemos evaluado la interacci\u00f3n del valproato, f\u00e1rmaco antiepil\u00e9ptico e inductor de teratog\u00e9nesis durante la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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