{"id":81059,"date":"2018-03-10T00:04:53","date_gmt":"2018-03-10T00:04:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/procesamiento-proteola%c2%adtico-de-receptores-transmembranales\/"},"modified":"2018-03-10T00:04:53","modified_gmt":"2018-03-10T00:04:53","slug":"procesamiento-proteola%c2%adtico-de-receptores-transmembranales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/procesamiento-proteola%c2%adtico-de-receptores-transmembranales\/","title":{"rendered":"Procesamiento proteol\u00edtico de receptores transmembranales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Diaz Rodriguez M Elena <\/strong><\/h2>\n<p>El receptor trka subre procesamiento proteol\u00edtico de su ectodominio. este proceso tiene lugar en la membrana plasm\u00e1tica y da como resultado la generaci\u00f3n de fragmentos activados a la c\u00e9lula y fosforilados en tirosina. estos fragmentos tienen capacidad de unirese a mol\u00e9culas de se\u00f1alizaci\u00f3n e iniciar una respuesta biol\u00f3gica en c\u00e9lulas pc12. Se general por la acci\u00f3n de un sistema de al menos dos metaloprotesas que act\u00faan sobre el receptor en dos puntos muy proximos. Es un proceso altamente regulado por v\u00edas de segundos mensajeros intracelulares como la v\u00eda de la pkc o la v\u00eda de calcio. adem\u00e1s de estas v\u00edas cl\u00e1sicamente implicadas en el procesamiento de prote\u00ednas de membrana, agentes inhibidores de la calmodulina son tambi\u00e9n capaces de estimular el procesamiento de trka. Lo hacen mediante una v\u00eda nueva e independiente de las anteriormente descritas como inductoras del procesamiento, si bien los efectores finales parecen ser los mismos. En el caso de trka no parece haber interacci\u00f3n directa de la calmodulina con su cola citos\u00f3lica, como se ha descrito en el caso de la l-selectina. Adem\u00e1s esta cola es dispensable para el procesamiento. La v\u00eda de los inhibidores de calmodulina es capaz de estimular el procesamiento de otras muchas prote\u00ednas de membrana como protgfa,bappo erbb4.  otro sistema proteol\u00edtico totalmente distinto afecta al tambi\u00e9n receptor tirosina quinasa erbb2. La aparici\u00f3n de su ectodominio soluble en c\u00e9lulas procedentes de tumores de mama no es producida por el sistema proteol\u00edtico antes descrito. En paralelo encontramos que este receptor sufre procesamiento en su extremo n-terminal gener\u00e1ndose dos formas truncadas de 150 y 165 kda. Esta truncaci\u00f3n se produce tras la activaci\u00f3n de la v\u00eda de la pkc, aunque con una cin\u00e9tica lenta(la m\u00e1xima generaci\u00f3n ocurre a las 3-6 horas de tratamiento). Ocurre de forma independiente a las v\u00edas cl\u00e1sicas de bios\u00edntesis y degradaci\u00f3n proteica y es llevada a c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Procesamiento proteol\u00edtico de receptores transmembranales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Procesamiento proteol\u00edtico de receptores transmembranales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Diaz Rodriguez M Elena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Atanasio Pandiella Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Miguel Ortiz melon <\/li>\n<li>piero Crespo baraja (vocal)<\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li>enrique Villar ledesma (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diaz Rodriguez M Elena El receptor trka subre procesamiento proteol\u00edtico de su ectodominio. este proceso tiene lugar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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