{"id":81067,"date":"2018-03-10T00:04:53","date_gmt":"2018-03-10T00:04:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-a-la-farmacologia-del-alprazolam\/"},"modified":"2018-03-10T00:04:53","modified_gmt":"2018-03-10T00:04:53","slug":"aportacion-a-la-farmacologia-del-alprazolam","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aportacion-a-la-farmacologia-del-alprazolam\/","title":{"rendered":"Aportaci\u00f3n a la farmacolog\u00eda del alprazolam"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cruz Ruiz Marta De La <\/strong><\/h2>\n<p>El alprazolam es una triazolobenzodiacepina con efecto ansiol\u00edtico y antidepresivo. En el presente trabajo se estudia el efecto de alprazolam sobre el consumo de ox\u00edgeno, actividad atpasa y la interacci\u00f3n con diversos neurotransmisores en preparaciones de \u00f3rgano aislado de cobaya y de rata \u00abin vitro\u00bb.  material y metodo  el consumo de ox\u00edgeno en cortes y homogeneizados de cerebro de rata \u00abin vitro\u00bb se determin\u00f3 mediante t\u00e9cnica manom\u00e9trica. La actividad atpasa se determin\u00f3 estimando el fosfato inorg\u00e1nico liberado a partir del adenos\u00edn-trifosfato (atp) en ausencia y en presencia de ouaba\u00edna. Para el estudio de las interacciones de \u00f3rgano aislado con los neurotransmisores, se determin\u00f3 el valor de pa2 cuando el antagonismo era de tipo competitivo.  resultados y discusi\u00f3n  el alprazolam a concentraciones elevadas disminuye el consumo de ox\u00edgeno de cortes de cerebro de rata \u00abin vitro\u00bb e inhibe la actividad atpasa de membrana sodio-potasio dependiente. En la preparaci\u00f3n de ileon aislado de cobaya se comport\u00f3 como antagonista competitivo de acetilcolina y de histamina, mientras que se comport\u00f3 como antagonista no competitivo de histamina en la preparaci\u00f3n de \u00fatero aislado de rata depolarizado conpotasio. el efecto anticolin\u00e9rgico pudiera explicar algunos efectos adversos de esta sustancia. Los otros hallazgos son completamente inespec\u00edficos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportaci\u00f3n a la farmacolog\u00eda del alprazolam<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportaci\u00f3n a la farmacolog\u00eda del alprazolam <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cruz Ruiz Marta De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fern\u00e1ndez Del Busto Ernesto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fern\u00e1ndez <\/li>\n<li>Francisco Javier Casta\u00f1eda casado (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Coca mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cruz Ruiz Marta De La El alprazolam es una triazolobenzodiacepina con efecto ansiol\u00edtico y antidepresivo. En el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,12692,189,483,7464,324,12451],"tags":[173197,45052,9211,4080,95353,898],"class_list":["post-81067","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-efecto-de-las-drogas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","category-psicofarmacologia","category-psicologia","category-valladolid","tag-cruz-ruiz-marta-de-la","tag-fernandez-del-busto-ernesto","tag-francisco-javier-castaneda-casado","tag-francisco-zaragoza-garcia","tag-jose-maria-coca-martin","tag-pedro-lorenzo-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81067","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=81067"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81067\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=81067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=81067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=81067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}