{"id":81141,"date":"1999-05-11T00:00:00","date_gmt":"1999-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reposta-humoral-en-el-model-experimental-de-tuberculosi-murina-importancia-dels-anta%c2%adgens-glicolipa%c2%addics-de-la-paret-cel-lular-de-m-tuberculosis\/"},"modified":"1999-05-11T00:00:00","modified_gmt":"1999-05-11T00:00:00","slug":"reposta-humoral-en-el-model-experimental-de-tuberculosi-murina-importancia-dels-anta%c2%adgens-glicolipa%c2%addics-de-la-paret-cel-lular-de-m-tuberculosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/reposta-humoral-en-el-model-experimental-de-tuberculosi-murina-importancia-dels-anta%c2%adgens-glicolipa%c2%addics-de-la-paret-cel-lular-de-m-tuberculosis\/","title":{"rendered":"Reposta humoral en el model experimental de tuberculosi murina. import\u00e1ncia dels ant\u00edgens glicolip\u00eddics de la paret cel-lular de m. tuberculosis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pere Joan Cardona Iglesias <\/strong><\/h2>\n<p>La tuberculosis es una enfermedad ocasionada por mycobacterium tuberculosis que mata anualmente unos 3 millones de personas. Uno de los factores que contribuyen a la falta de control de esta enfermedad es el d\u00e9ficit de instrumentos eficaces de diagn\u00f3stico, basados todav\u00eda mayoritariamente en la prueba de la tuberculina, la realizaci\u00f3n de radiograf\u00edas de t\u00f3raz i la b\u00fasqueda de bacilos \u00e1cido-alcohol resistentes en el esputo de los enfermos.  en este trabajo se ha investigado la producci\u00f3n de anticuerpos contra glicol\u00edpidos presentes en el exterior de la pared celular de m. Tuberculosis. debido a su disposici\u00f3n, se cree que estos ant\u00edgenos pueden desencadenar alg\u00fan tipo de respuesta inmune en el hu\u00e9sped infectado que podr\u00eda incluir la producci\u00f3n de anticuerpos. Para determinar la cin\u00e9tica de la s\u00edntesis de anticuerpos contra los ant\u00edgenos cord factor, diaciltrehalosas, glicol\u00edpidos fen\u00f3licos y sulfl\u00edpido i se utiliz\u00f3 el modelo de tuberculosis en el rat\u00f3n, infectado mediante un aerosol, para imitar diferentes circunstancias en la historia natural de la tuberculosis en el hombre: infecci\u00f3n, reinfecci\u00f3n, reactivaci\u00f3n, profilaxis y tratamiento.  puesto que una de las grandes diferencias histopatol\u00f3gicas en las lesiones provocadas por m. Tuberculosis en el hombre y el rat\u00f3n es que en este \u00faltimo no se detecta necrosis intragranulomatosa, se dise\u00f1\u00f3 un modelo \u00abhumanizado\u00bb basado en la introducci\u00f3n intranasal de lipopolisac\u00e1rido para recrear esta caracter\u00edstica en el rat\u00f3n.  los resultados han mostrado que la producci\u00f3n de anticuerpos era \u00fanicamente del isotipo igm, que se desencadenaba a partir del d\u00eda 60 post-infecci\u00f3n, y que eran de mayor envergadura contra los ant\u00edgenos glicop\u00eddicos que contra los pept\u00eddicos. Particularmente la respeusta era m\u00e1s intensa contra las diaciltrehalosas y el sulfol\u00edpido i, mostrando en el modelo de infecci\u00f3n, una correlaci\u00f3n linear entre los t\u00edtulos de anticuerpos y la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reposta humoral en el model experimental de tuberculosi murina. import\u00e1ncia dels ant\u00edgens glicolip\u00eddics de la paret cel-lular de m. tuberculosis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reposta humoral en el model experimental de tuberculosi murina. import\u00e1ncia dels ant\u00edgens glicolip\u00eddics de la paret cel-lular de m. tuberculosis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pere Joan Cardona Iglesias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Ausina Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillem Prats <\/li>\n<li>Javier Ariza (vocal)<\/li>\n<li>Alberto Pahissa berga (vocal)<\/li>\n<li>joan Gavalda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pere Joan Cardona Iglesias La tuberculosis es una enfermedad ocasionada por mycobacterium tuberculosis que mata anualmente unos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,1085,139,278,156,1323,2601],"tags":[1089,96447,173304,173305,118028,13974],"class_list":["post-81141","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-enfermedades-infecciosas","category-medicina-interna","category-microbiologia","category-patologia","category-patologia-experimental","category-procesos-microbianos","tag-alberto-pahissa-berga","tag-guillem-prats","tag-javier-ariza","tag-joan-gavalda","tag-pere-joan-cardona-iglesias","tag-vicente-ausina-ruiz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=81141"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81141\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=81141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=81141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=81141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}