{"id":8121,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/hemorragia-digestiva-asociada-al-consumo-de-aines\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"hemorragia-digestiva-asociada-al-consumo-de-aines","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/hemorragia-digestiva-asociada-al-consumo-de-aines\/","title":{"rendered":"Hemorragia digestiva asociada al consumo de aines."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Teresa Arroyo Villarino <\/strong><\/h2>\n<p>Con el uso combinado de la historia clinica y el test objetivo de la actividad ciclooxigenasa plaquetaria, la hemorragia digestiva se encuentra asociada al consumo de aines, especialmente aspirina (aas), en aproximadamente el 80% de los casos, si bien solo un 1% de los pacientes que consumen aines presentan una hda por un mecanismo que todavia se desconoce. Por ello los objetivos de este trabajo han sido identificar en aquellos sujetos con episodios de hd asociados a aas, la posible existencia de una respuesta hemorragica anomala a la utilizacion del farmaco y los posibles mecanismos dependientes o independientes de la actividad plaquetaria envueltos en el proceso. Para ello incluimos 58 pacientes, con al menos un episodio previo de hda asociada a aas, tras comprobar mediante endoscopia la cicatrizacion de su lesion y 43 controles sin antecedentes de patolog\u00eda g-d o historia de hda. Tras la administracion de 325 mg. De aas, a cada uno de ellos se les realizo secuencialmente tiempos de hemorragia cutanea (thc) y determinacion de metabolitos de aas en sangre por hplc. Tambien se les realizo estudio de agregacion plaquetaria, coagulacion y dosificacion de factores viiic, viivw y viiiag.  en respuesta a los objetivos formulados, y de acuerdo con nuestros resultados, establecemos las siguientes conclusiones: 1) una proporcion significativa de pacientes con historia de hemorragia digestiva asociada al consumo de aspirina, presentan una anormal prolongacion del tiempo de hemorragia cutaneo en respuesta al uso del acido acetilsalicilico, que denominamos hiperrespuesta. 2) la presencia de hiperrespuesta al acido acetilsalicilico es el unico factor independiente asociado a la presencia de hemorragia digestiva en esta poblacion. Este factor es especialmente importante en la poblacion menor de 60 a\u00f1os. 3) esta hiperrespuesta se asocia de manera significativa con una mayor tendencia a la recidiva hemorragica y con una mayor severidad del epi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hemorragia digestiva asociada al consumo de aines.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hemorragia digestiva asociada al consumo de aines. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Teresa Arroyo Villarino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Gabriel Guill\u00e9n Mart\u00ednez <\/li>\n<li>Fernando Escolar Castellon (vocal)<\/li>\n<li>Francisco Gomez Casal (vocal)<\/li>\n<li> Samperiz Legarre Angel Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Teresa Arroyo Villarino Con el uso combinado de la historia clinica y el test objetivo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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