{"id":81223,"date":"2018-03-10T00:05:06","date_gmt":"2018-03-10T00:05:06","guid":{"rendered":""},"modified":"2018-03-10T00:05:06","modified_gmt":"2018-03-10T00:05:06","slug":"eficacia-de-diferentes-protocolos-de-administracion-de-s-adenosilmetionina-frente-a-la-hepatotoxicidad-y-nefrotoxicidad-de-la-ciclosporina-a-implicacion-de-la-homeostasis-interorganos-del-glutation","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/eficacia-de-diferentes-protocolos-de-administracion-de-s-adenosilmetionina-frente-a-la-hepatotoxicidad-y-nefrotoxicidad-de-la-ciclosporina-a-implicacion-de-la-homeostasis-interorganos-del-glutation\/","title":{"rendered":"Eficacia de diferentes protocolos de administracion de s-adenosilmetionina frente a la hepatotoxicidad y nefrotoxicidad de la ciclosporina a. implicacion de la homeostasis interorganos del glutation"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amador Felipe Conde <\/strong><\/h2>\n<p>La investigaci\u00f3n realizada ten\u00eda un doble objetivo: determinar si las alteraciones de la homeostasis de glutati\u00f3n(gsh) est\u00e1n involucradas en el efecto hepatot\u00f3xico y nefrot\u00f3xico de la ciclosporina a(cya), y evaluar la eficacia de un hepatoprotector relacionado con el gsh, la s-adenosilmetionina(same), para prevenir, antagonizar o restaurar los cambios inducidos por el inmunosupresor. Se utilizaron ratas wistar y se aplicaron tres protocolos de administraci\u00f3n diferentes: uno preventivo o de pretratamiento con same antes de administrar cya, otro de cotratamiento o administraci\u00f3n simult\u00e1nea de ambos f\u00e1rmacos y, por \u00faltimo, otro curativo o de postratamiento con sam e despu\u00e9s de cya. el tratamiento con cya, de corte (1 semana) y larga (4 semanas) duraci\u00f3n, alter\u00f3 la homeostasis hep\u00e1tica e inter\u00f3ganos del gsh: deplecion\u00f3 los dep\u00f3sitos hep\u00e1ticos del trip\u00e9ptido, alter\u00f3 el estado redox del gsh en h\u00edgado y ri\u00f1\u00f3n de forma sincr\u00f3nica, aument\u00f3 la lipoperoxidaci\u00f3n en ambos \u00f3rganos, aument\u00f3 el gsh plasm\u00e1tico y redujo el contenido biliar de glutati\u00f3n oxidado y reducido; este \u00faltimo efecto depende de la dosis administrada. La cya no alter\u00f3 la actividad glutati\u00f3n s-transferasa hep\u00e1tica pero aument\u00f3 la actividad -glutamilciste\u00edna sintetasa, glutati\u00f3n peroxidasa y   -glutamiltransferasa en h\u00edgado y\/o ri\u00f1\u00f3n. El tratamiento con same preven\u00eda, antagonizaba o revert\u00eda total o parcialmente las alteraciones inducidas por la cya en la homeostasis hep\u00e1tica y biliar del glutati\u00f3n, pero es totalmente ineficaz para el ri\u00f1\u00f3n. la capacidad de la same para prevenir, antagonizar y restaurar las alteraciones inducidas por cya en la homeostasis hepatobiliar del gsh podr\u00eda deberse a su participaci\u00f3n en tres procesos hepatocelulares diferentes:1) actuando como donante de grupos metilo, modulando as\u00ed las propiedades de la membrana plasm\u00e1tica; 2) actuando como precursor del gsh y, 3) manteniendo el pool de prote\u00ednas plasm\u00e1ticas y hep\u00e1ticas y su reciclaje en la membrana plasm\u00e1tica del hepatocito.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia de diferentes protocolos de administracion de s-adenosilmetionina frente a la hepatotoxicidad y nefrotoxicidad de la ciclosporina a. implicacion de la homeostasis interorganos del glutation<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia de diferentes protocolos de administracion de s-adenosilmetionina frente a la hepatotoxicidad y nefrotoxicidad de la ciclosporina a. implicacion de la homeostasis interorganos del glutation <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amador Felipe Conde <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/11\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Jimenez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>alejandro Esteller  perez (vocal)<\/li>\n<li>Javier Gonz\u00e1lez gallego (vocal)<\/li>\n<li>gin\u00e9s Salido ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amador Felipe Conde La investigaci\u00f3n realizada ten\u00eda un doble objetivo: determinar si las alteraciones de la homeostasis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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