{"id":81236,"date":"2018-03-10T00:05:06","date_gmt":"2018-03-10T00:05:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-actividad-del-sistema-noradrenergico-central-por-farmacos-antidepresivos-estudio-mediante-microdialisis-cerebral-in-vivo\/"},"modified":"2018-03-10T00:05:06","modified_gmt":"2018-03-10T00:05:06","slug":"regulacion-de-la-actividad-del-sistema-noradrenergico-central-por-farmacos-antidepresivos-estudio-mediante-microdialisis-cerebral-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/regulacion-de-la-actividad-del-sistema-noradrenergico-central-por-farmacos-antidepresivos-estudio-mediante-microdialisis-cerebral-in-vivo\/","title":{"rendered":"Regulaci\u00f3n de la actividad del sistema noradren\u00e9rgico central por f\u00e1rmacos antidepresivos. estudio mediante microdi\u00e1lisis cerebral in vivo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda Mateo Gonzalez <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os la hip\u00f3tesis mas evaluada en el estudio de la depresi\u00f3n end\u00f3gena ha sido la posible existencia de un deficit en la neurotransmisi\u00f3n noradren\u00e9rgica y\/o seroton\u00e9rgica. Asi, se han estudiado posibles alteraciones en los neuroreceptores implicados y en sus sistemas de acople.  el trabajo realizado se ha basado en el estudio de la regulaci\u00f3n que ejercen diferentes farmacos antidepresivos en la actividad del sistema noradren\u00e9rgico central. Para ello se ha empleado la t\u00e9cnica de microdi\u00e1lisis cerebral en rata despierta y se han evaluado los niveles de noradrenalina en las areas del locus coeruleus y en corteza cingular. Los f\u00e1rmacos empleados han sido: el antidepresivo desipramina, un inhibidor selectivo de la recaptaci\u00f3n de noradrenalina; el antidepresivo clorgilina, un inhibidor de la enzima monoamino oxidasa y el antidepresivo citalopram, un inhibidor selectivo de la recaptaci\u00f3n de serotonina.  los resultados obtenidos muestran que la regulaci\u00f3n in vivo del sistema noradren\u00e9rgico central por f\u00e1rmacos inhibidores de la recaptaci\u00f3n de neurotransmisores implica aciones, en ocasiones diferenciadas, tanto a nivel somatodentr\u00edtico como a nivel de terminales nerviosos.  los presentes resultados sugieren tambi\u00e9n una regulaci\u00f3n in vivo del sistema noradren\u00e9rgico central por f\u00e1rmacos con actividad sobre el sistema serotorn\u00e9rgico y particularmente, por los antidepresivos inhibidores de la recaptaci\u00f3n de serotonina.  en el presente trabajo se demuestra la existencia de una modulaci\u00f3n diferente de los adrenoceptores a2 tras el tratamiento cr\u00f3nico con f\u00e1rmacos antidepresivos seg\u00fan la localizaci\u00f3n y funciones mediadas por esos adrenoceptores en el sistema noradren\u00e9rgico central. Este hallazgo in vivo pudiera tener importancia en la interpretaci\u00f3n de las acciones clinicas de los farmacos antidepresivos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la actividad del sistema noradren\u00e9rgico central por f\u00e1rmacos antidepresivos. estudio mediante microdi\u00e1lisis cerebral in vivo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la actividad del sistema noradren\u00e9rgico central por f\u00e1rmacos antidepresivos. estudio mediante microdi\u00e1lisis cerebral in vivo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda Mateo Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/11\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Javier Meana Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas andres Garcia sevilla <\/li>\n<li>carmen Mar\u00eda Gonzalez garcia (vocal)<\/li>\n<li>Mar\u00eda Luisa Laorden carrasco (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda Mateo Gonzalez En los \u00faltimos a\u00f1os la hip\u00f3tesis mas evaluada en el estudio de la depresi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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