{"id":81244,"date":"2018-03-10T00:05:06","date_gmt":"2018-03-10T00:05:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-de-la-cafea%c2%adna-en-pacientes-cirroticos-y-correlacion-con-parametros-clinicos-y-bioquimicos-de-disfuncion-hepatica\/"},"modified":"2018-03-10T00:05:06","modified_gmt":"2018-03-10T00:05:06","slug":"farmacocinetica-de-la-cafea%c2%adna-en-pacientes-cirroticos-y-correlacion-con-parametros-clinicos-y-bioquimicos-de-disfuncion-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-de-la-cafea%c2%adna-en-pacientes-cirroticos-y-correlacion-con-parametros-clinicos-y-bioquimicos-de-disfuncion-hepatica\/","title":{"rendered":"Farmacocin\u00e9tica de la cafe\u00edna en pacientes cirr\u00f3ticos y correlaci\u00f3n con par\u00e1metros clinicos y bioquimicos de disfunci\u00f3n hepatica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Marco Garbayo Jos\u00e9 Luis <\/strong><\/h2>\n<p>La presente tesis doctoral tiene por objetivos: establecer la farmacocin\u00e9tica de la cafe\u00edna en pacientes afectos de cirrosis hepatica, incluyendo su biodisponibilidad en magnitud. Establecer la correlaci\u00f3n entre los par\u00e1metros farmacocin\u00e9ticos de la cafeina y los parametros bioqu\u00edmicos utilizados en la cuantificaci\u00f3n del da\u00f1o hep\u00e1tico y con el indice pronostico establecido por child y pugh.  en el estudio se han incluido 14 pacientes cirr\u00f3ticos. A cada paciente se administr\u00f3 dos dosis de cafe\u00edna, una de 200 mg de cafe\u00edna citrato en perfusi\u00f3n intravenosa de corta duraci\u00f3n y las 24 horas una segunda dosis oral de cafe\u00edna monohidrato equivalente a 3 mg de cafeina anhidra por kilogramo de peso.  las muestras plasm\u00e1ticas se han valorado mediante emit.  el an\u00e1lisis farmacocin\u00e9tico de los datos se ha realizado con el programa pcnonlin 4.2. Se han elaborado 14 modelos matem\u00e1ticos para el ajustado de los datos de concentraci\u00f3n plam\u00e1tica tiempo.  en cada paciente se ha realizado el ajustado de los datos para las dos formas de administraci\u00f3n de forma individual y conjunta.  en 13 de los 14 pacientes se demuestra el comportamiento bicompartimental de la cafe\u00edna. Se estiman las constantes farmacocin\u00e9ticas del f\u00e1rmaco y se demuestra que la biodisponibilidad en magnitud por v\u00eda oral de la cafe\u00edna es completa. No se consigue establecer una correlaci\u00f3n estad\u00edsticamente significativa  este el aclaramiento de cafe\u00edna y los par\u00e1metros bioqu\u00edmicos de disfunci\u00f3n hep\u00e1tica ni con el indice de child y pugh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica de la cafe\u00edna en pacientes cirr\u00f3ticos y correlaci\u00f3n con par\u00e1metros clinicos y bioquimicos de disfunci\u00f3n hepatica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica de la cafe\u00edna en pacientes cirr\u00f3ticos y correlaci\u00f3n con par\u00e1metros clinicos y bioquimicos de disfunci\u00f3n hepatica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Marco Garbayo Jos\u00e9 Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victor Jimenez Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marina Herraez dominguez <\/li>\n<li>M\u00aa Jos\u00e9 Faus dader (vocal)<\/li>\n<li>Jos\u00e9 Vila salinas (vocal)<\/li>\n<li>\u00e1ngel Mu\u00f1oz ru\u00edz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marco Garbayo Jos\u00e9 Luis La presente tesis doctoral tiene por objetivos: establecer la farmacocin\u00e9tica de la cafe\u00edna [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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