{"id":81337,"date":"2018-03-10T00:05:14","date_gmt":"2018-03-10T00:05:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-clorhidrato-de-nortriptilina-sobre-diversas-preparaciones-de-organo-aislado-de-cobaya-y-de-rata-in-vitro\/"},"modified":"2018-03-10T00:05:14","modified_gmt":"2018-03-10T00:05:14","slug":"efecto-del-clorhidrato-de-nortriptilina-sobre-diversas-preparaciones-de-organo-aislado-de-cobaya-y-de-rata-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-clorhidrato-de-nortriptilina-sobre-diversas-preparaciones-de-organo-aislado-de-cobaya-y-de-rata-in-vitro\/","title":{"rendered":"Efecto del clorhidrato de nortriptilina sobre diversas preparaciones de \u00f3rgano aislado de cobaya y de rata \u00abin vitro\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vicario Zubizarreta M. Jos\u00e9 <\/strong><\/h2>\n<p>La nortriptilina es un f\u00e1rmaco antidepresivo tric\u00edclico bloqueante relativamente selectivo de la recaptaci\u00f3n neuronal de noradrenalina. En este trabajo se estudia su efecto sobre conducto deferente y \u00fatero aislados de rata e ileon aislado de cobaya.  material y metodos  se utilizaron preparaciones de conducto deferente de rata para el estudio de la interacciones de nortriptilina con noradrenalina y dopamina; \u00fatero aislado de rata para las interacciones con serotonina, acetilcolina, oxitocina, cloruro de bario y cloruro de potasio e ileon aislado de cobaya para las interacciones con 4-aminopiridina y cloruro de potasio.  resultados y discusion  el clorhidrato de nortriptilina potencia las respuestas del conducto deferente aislado de rat a noradrenalina cuando el medio de incubaci\u00f3n es soluci\u00f3n de krebes henseleit normal, pero cuando a este medio de incupaci\u00f3n se a\u00f1ade coca\u00edna, 17 beta estradiol y proparanolol se comprota como ante aislado de rata. La nortriptilina se comporta como antagonista no competitivo de depamina cuando el medio de incubaci\u00f3n es solucion de krebs-henseleit y cunado se a\u00f1de a este medio de incubaci\u00f3n: coca\u00edna, 17 beta estradiol y propranolol. El clorhidrato de nortriptilina antagoniza la contracci\u00f3n inducida por 4-aminopiridina y cloruro d epotasio en la preparaci\u00f3n de ileon aislado de cobaya incubado en soluci\u00f3n tyrode. El clorhidrato de notriptilina antagoniza de forma no competitiva la contracci\u00f3n inducida por serotonina, acetilcolina, oxitocina, cloruro de bario y cloruro de potasio en la preparaci\u00f3n de \u00fatero aislado de lina es un f\u00e1rmaco estabilizador inespec\u00edfico de membrana que bloquea canales de sodio voktaje-dependientes e impide la entrada de calcio, por ello se comporta como antagonista no competitivo de los agonistas utilizados en este trabajo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del clorhidrato de nortriptilina sobre diversas preparaciones de \u00f3rgano aislado de cobaya y de rata \u00abin vitro\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del clorhidrato de nortriptilina sobre diversas preparaciones de \u00f3rgano aislado de cobaya y de rata \u00abin vitro\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vicario Zubizarreta M. Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Velasco Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Fernando Fern\u00e1ndez de la gandara (vocal)<\/li>\n<li>Luis San rom\u00e1n del barrio (vocal)<\/li>\n<li> Fern\u00e1ndez del busto ernesto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicario Zubizarreta M. Jos\u00e9 La nortriptilina es un f\u00e1rmaco antidepresivo tric\u00edclico bloqueante relativamente selectivo de la recaptaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,12692,189,483,7464,324,12451],"tags":[12654,45052,12638,7196,4664,173612],"class_list":["post-81337","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-efecto-de-las-drogas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","category-psicofarmacologia","category-psicologia","category-valladolid","tag-alfonso-velasco-martin","tag-fernandez-del-busto-ernesto","tag-fernando-fernandez-de-la-gandara","tag-luis-san-roman-del-barrio","tag-pedro-sanchez-garcia","tag-vicario-zubizarreta-m-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=81337"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81337\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=81337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=81337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=81337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}