{"id":81365,"date":"2018-03-10T00:05:14","date_gmt":"2018-03-10T00:05:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-marcadores-de-proliferacion-celular-fase-5-indice-proliferativo-p-105-y-ki-67-como-factores-pronosticos-en-el-carcinoma-de-celulas-renales\/"},"modified":"2018-03-10T00:05:14","modified_gmt":"2018-03-10T00:05:14","slug":"estudio-de-los-marcadores-de-proliferacion-celular-fase-5-indice-proliferativo-p-105-y-ki-67-como-factores-pronosticos-en-el-carcinoma-de-celulas-renales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-los-marcadores-de-proliferacion-celular-fase-5-indice-proliferativo-p-105-y-ki-67-como-factores-pronosticos-en-el-carcinoma-de-celulas-renales\/","title":{"rendered":"Estudio de los marcadores de proliferaci\u00f3n celular: fase 5, indice proliferativo, p-105 y ki-67, como factores pron\u00f3sticos en el carcinoma de celulas renales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alfredo Rodriguez Rodriguez <\/strong><\/h2>\n<p>Introduccion  aunque el estadio tumoral y el grado histol\u00f3gico son par\u00e1metros pron\u00f3sticos importantes para los pacientes afectos de carcinoma renal, la supervivencia postnefrectom\u00eda es a menudo dificil de predecir. Es por ello necesario encontrar nuevos marcadores que nos permitan la identificaci\u00f3n de los pacientes con alto riesgo de progresi\u00f3n. El objetivo del estudio fue determinar el valor pron\u00f3stico del contenido adn, fase s y de los ant\u00edgenos nucleares ki-67 y p-105 (asociados a la proliferaci\u00f3n) en el carcinoma de c\u00e9lulas renales (ccr).  material y m\u00e9todos  se analizaron mediante citometr\u00eda de flujo 106 tumores procedentes de una serie de 146 pacientes sometidos a nefrectom\u00eda radical por ccr con un seguimiento m\u00ednimo superior a 5 a\u00f1os. Sobre tejido desparafinado se determin\u00f3 la ploid\u00eda, fracci\u00f3n celular en fase s, indice proliferativo y en 70 casos la expresi\u00f3n del ant\u00edgeno nuclear p-105 utilizando para ello un anticuerpo monoclonal espec\u00edfico. Adem\u00e1s, en 80 pacientes se determin\u00f3 la expresi\u00f3n del ant\u00edgeno ki-67 mediante t\u00e9cnicas de inmunohistoqu\u00edmica. los datos obtenidos del seguimiento de los pacientes y los resultados del estudio de la ploidia y de los marcadores de proliferaci\u00f3n fueron comparados con los factores pron\u00f3sticos cl\u00e1sicos.  resultados  la ploid\u00eda se correlacion\u00f3 de forma significativa con el estadio (p=0,001), grado (p=0,003) y tama\u00f1o tumoral (p&lt;0,0001) pero no con la supervivencia. la fracci\u00f3n celular en fase s y el \u00edndice proliferativo no mostraron relaci\u00f3n significativa con estadio ni el grado pero s\u00ed con el tama\u00f1o tumoral (p=0,001) y la supervivencia (p=0,002). La expresi\u00f3n del ant\u00edgeno nuclear p-105 oscil\u00f3 entre 19,5 y 94,10% con una media de 69,61% y en nuestra serie, no present\u00f3 relaci\u00f3n significativa con los marcadores pron\u00f3sticos cl\u00e1sicos ni con la supervivencia (p&gt;0,05). La expresi\u00f3n tumoral de ki-67 oscil\u00f3 entre 0 y 36,5% con una media de 3,42%. Di<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los marcadores de proliferaci\u00f3n celular: fase 5, indice proliferativo, p-105 y ki-67, como factores pron\u00f3sticos en el carcinoma de celulas renales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los marcadores de proliferaci\u00f3n celular: fase 5, indice proliferativo, p-105 y ki-67, como factores pron\u00f3sticos en el carcinoma de celulas renales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alfredo Rodriguez Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/11\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Carretero Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan S\u00e1nchez-lloret tortosa <\/li>\n<li>Manuel Gil salom (vocal)<\/li>\n<li>Jes\u00fas Casti\u00f1eiras fern\u00e1ndez (vocal)<\/li>\n<li>octavio Arango toro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alfredo Rodriguez Rodriguez Introduccion aunque el estadio tumoral y el grado histol\u00f3gico son par\u00e1metros pron\u00f3sticos importantes para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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