{"id":81468,"date":"1999-02-12T00:00:00","date_gmt":"1999-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/noves-aproximacons-sintetiques-a-acids-grassos-ciclopropenics\/"},"modified":"1999-02-12T00:00:00","modified_gmt":"1999-02-12T00:00:00","slug":"noves-aproximacons-sintetiques-a-acids-grassos-ciclopropenics","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/noves-aproximacons-sintetiques-a-acids-grassos-ciclopropenics\/","title":{"rendered":"Noves aproximacons sintetiques a acids grassos ciclopropenics"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Cano Biosca <\/strong><\/h2>\n<p>La s\u00edntesis cl\u00e1sica de \u00e1cidos grasos cicloprop\u00e9nicos se basa en una reacci\u00f3n de ciclopropenaci\u00f3n de un acetileno con diazoacetato de etilo seguida de la descarboxilaci\u00f3n del \u00e1cido cicloprop\u00e9nico. Con el prop\u00f3sito de optimizar esta aproximaci\u00f3n se ha realizado la primera reacci\u00f3n de ciclopropenaci\u00f3n en fase s\u00f3lida a partir del diazo-acetato soportado sobre un pol\u00edmero en presencia de un catalizador de rh(ii) y diferentes acetilenos. Se obtienen de esta manera los correspondientes derivados cicloprop\u00e9nicos evitando la formaci\u00f3n de productos secundarios observados en la misma reacci\u00f3n en disoluci\u00f3n. En segundo lugar, centrando la atenci\u00f3n en la etapa de descarboxilaci\u00f3n, se ha obtenido la primera formaci\u00f3n sin precedentes de derivados n-(3-ciclopropenil)-ftalimida (i) a partir de la reacci\u00f3n de descarboxilaci\u00f3n radicalaria del correspondiente n-(3-ciclopropenilcarboniloxi) ftalimida. Estudios biol\u00f3gicos preliminares de los derivados tipo i muestran una elevada actividad antitumoral sobredistintas linia celulares. Se demuestra en latesis que esta actividad resulta \u00fanicamente de la combinaci\u00f3n de las dos subestructuras de ftalimida y ciclopropeno presentada en el computo tipo i.  estudiando otras aproximaciones sint\u00e9ticas a trav\u00e9s de la reducci\u00f3n de ciclopropenonas con amino boranos, se ha observado una influencia dr\u00e1stica de los sustituyentes en posici\u00f3n 1 y 2 del anillo cicloprop\u00e9nico. De manera que derivados arom\u00e1ticos dan rendimientos de reducci\u00f3n quantitaticos mientras que para un equivalente alif\u00e1tico se ha optimizado en esta tesis un rendimiento de reducci\u00f3n hasta un 35%.  finalmente, se ha realizado la primera detecci\u00f3n por epr de radicales ciclopropen\u00edlicos mediante la tecnica de spin-trapping con dmpo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Noves aproximacons sintetiques a acids grassos ciclopropenics<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Noves aproximacons sintetiques a acids grassos ciclopropenics <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Cano Biosca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Camps Diez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jaume Vilarrasa llorens <\/li>\n<li>josep Mar\u00eda Moret\u00f3 canela (vocal)<\/li>\n<li>josep Bonjoch sese (vocal)<\/li>\n<li>lLuis Julia bages (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Cano Biosca La s\u00edntesis cl\u00e1sica de \u00e1cidos grasos cicloprop\u00e9nicos se basa en una reacci\u00f3n de ciclopropenaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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