{"id":815,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":""},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"sintesis-asimetrica-de-compuestos-de-interes-biologico-sintesis-enantioselectiva-y-estereodivergente-de-3-hidroxiaspartatos-sintesis-enantioespecifica-del-acido-5-o-carbamoilpolioxamico-aproximacio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-asimetrica-de-compuestos-de-interes-biologico-sintesis-enantioselectiva-y-estereodivergente-de-3-hidroxiaspartatos-sintesis-enantioespecifica-del-acido-5-o-carbamoilpolioxamico-aproximacio\/","title":{"rendered":"Sintesis asimetrica de compuestos de interes biologico: sintesis enantioselectiva y estereodivergente de 3-hidroxiaspartatos. sintesis enantioespecifica del acido 5-o-carbamoilpolioxamico. aproximacion a la sintesis enantioselectiva de imidazolglicerol fosfato y analogos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Paz Casta\u00f1al M. Paz <\/strong><\/h2>\n<p>Se ha desarrollado una sintesis de (2s, 3s) y (2s, 3r) n-pf-3-hidroxiaspartatos en 3 pasos a partir de acido l-aspartico basada en la hidroxilacion de enolatos de n-pf-aspartatos. La metodolog\u00eda desarrollada permite obtener selectivamente ambos diastereoisomeros en altos rendimientos y y se ha demostrado que la sintesis es enantioespecifica.  se ha desarrollado una sintesis enantioespecifica de (2s) n-pf-dideshidroglutamato de dimetilo (4) en 4 pasos a partir de acido l-glutamico con un rendimiento global del 74%. El deshidroglutamato se empleo en una sintesis corta de acido 5-o-carbamoil-polioxamico, un componente de los antibioticos de la familia de las polioxinas. Ademas se sintetizaron 3-metilglutamatos por adicion de cupratos a 4, y se ha demostrado que esta reaccion transcurre con retencion completa de la integridad quiral del carbono 2, pese a las condiciones fuertemente basicas utilizadas.  se ha estudiado una metodolog\u00eda general para la sintesis de imidazolglicerol fosfato (igp, 166) y analogos. La secuencia empleada se basa en la funcionalizacion estereoselectiva de una aciloxazolidinona y permite funcionalizar facilmente las posiciones 1 y 2 de la cadena de igp, lo que puede dar acceso a gran cantidad de analogos de igp.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis asimetrica de compuestos de interes biologico: sintesis enantioselectiva y estereodivergente de 3-hidroxiaspartatos. sintesis enantioespecifica del acido 5-o-carbamoilpolioxamico. aproximacion a la sintesis enantioselectiva de imidazolglicerol fosfato y analogos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis asimetrica de compuestos de interes biologico: sintesis enantioselectiva y estereodivergente de 3-hidroxiaspartatos. sintesis enantioespecifica del acido 5-o-carbamoilpolioxamico. aproximacion a la sintesis enantioselectiva de imidazolglicerol fosfato y analogos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Paz Casta\u00f1al M. Paz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Sardina L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Suau Suarez <\/li>\n<li>Jes\u00fas Ezquerra Carrera (vocal)<\/li>\n<li>Claudio Palomo Nicolau (vocal)<\/li>\n<li>Emilio Qui\u00f1oa Cabana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paz Casta\u00f1al M. Paz Se ha desarrollado una sintesis de (2s, 3s) y (2s, 3r) n-pf-3-hidroxiaspartatos en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17,416,977],"tags":[3064,3065,3062,3063,3061,2512],"class_list":["post-815","post","type-post","status-publish","format-standard","hentry","category-quimica","category-quimica-organica","category-santiago-de-compostela","tag-claudio-palomo-nicolau","tag-emilio-quinoa-cabana","tag-francisco-javier-sardina-lopez","tag-jesus-ezquerra-carrera","tag-paz-castanal-m-paz","tag-rafael-suau-suarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=815"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/815\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}