{"id":81536,"date":"1999-09-12T00:00:00","date_gmt":"1999-09-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-por-atp-extracelular-de-las-corrientes-de-calcio-y-la-respuesta-secretora-de-las-celulas-cromafines-bovinas\/"},"modified":"1999-09-12T00:00:00","modified_gmt":"1999-09-12T00:00:00","slug":"modulacion-por-atp-extracelular-de-las-corrientes-de-calcio-y-la-respuesta-secretora-de-las-celulas-cromafines-bovinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-por-atp-extracelular-de-las-corrientes-de-calcio-y-la-respuesta-secretora-de-las-celulas-cromafines-bovinas\/","title":{"rendered":"Modulaci\u00f3n por atp extracelular de las corrientes de calcio y la respuesta secretora de las c\u00e9lulas cromafines bovinas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guido Ulate Montero <\/strong><\/h2>\n<p>Por medio de la t\u00e9cnica de patch clamp, que permiti\u00f3 medir las corrientes i\u00f3nicas y los cambios de capacitancia como medida de exocitosis, cambiando con la microfluorometr\u00eda de la sonda fura-2, para medir la (cah)ic, se estudi\u00f3 el efecto modulador del atp extracelular sobre la respuesta secretora de catecolaminas de las c\u00e9lulas cromafines bovinas.  los resultados obtenidos indican que el atp inhibo la entrada de ca++ estimulada por la despolarizaci\u00f3n el\u00e9ctrica de la membrana celular y secundariamente, la respuesta secretora. El atp ejerce este efecto actuando sobre los 3 tipos de canales de ca++ (l,n y p\/*a). Adem\u00e1s, el atp no modific\u00f3 la dependencia de la exocitosis de la entrada de calcio ni la respuesta secretora inducida por la di\u00e1lisis intracelular con soluciones tamponadas de ca++, por lo que no parece ejercer un efecto directo sobre la maquinaria secretora. la inhibici\u00f3n por atp de la secreci\u00f3n es dependiente de voltaje.As\u00ed mismo, cuando la entrada de ca++ gatura la respuesta secretora causando el agotamiento del contingente de ves\u00edculas r\u00e1pidamente liberable, se anula el efecto inhibitorio del atp sobre la exocitosis.  estos hallazgos refuerzan la hip\u00f3tesis de una modulaci\u00f3na utocrina de la respuesta secretora de las c\u00e9lulas cromafines por el atp coliberado con las catecolaminas, adem\u00e1s, contribuyen a &#8212; dicho efecto regulador de una manera din\u00e1mica, pues su magnitud depender\u00e1 no solo del grado de ocupaci\u00f3n de los receptores purin\u00e9rgicos sino tambi\u00e9n de la actividad el\u00e9ctrica y secretora de la c\u00e9lula.En consecuencia y como resultado de los experimentos de esta tesis, cabe propner que el efecto inhibitorio del atp sobre la secreci\u00f3n tendr\u00e1 lugar fundamentalmente en condiciones basales pero se vera notablmente disminuid\u00f3 en el estr\u00e9s.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n por atp extracelular de las corrientes de calcio y la respuesta secretora de las c\u00e9lulas cromafines bovinas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n por atp extracelular de las corrientes de calcio y la respuesta secretora de las c\u00e9lulas cromafines bovinas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guido Ulate Montero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Rodr\u00edguez Artalejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Mar\u00eda Trifaro jose (vocal)<\/li>\n<li>Antonio Sillero repullo (vocal)<\/li>\n<li>Mar\u00eda  teresa Miras portugal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guido Ulate Montero Por medio de la t\u00e9cnica de patch clamp, que permiti\u00f3 medir las corrientes i\u00f3nicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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