{"id":81601,"date":"2018-03-10T00:05:30","date_gmt":"2018-03-10T00:05:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/repercusiones-clinico-biologicas-de-un-extracto-oral-de-alternaria-en-el-asma-infantil\/"},"modified":"2018-03-10T00:05:30","modified_gmt":"2018-03-10T00:05:30","slug":"repercusiones-clinico-biologicas-de-un-extracto-oral-de-alternaria-en-el-asma-infantil","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/repercusiones-clinico-biologicas-de-un-extracto-oral-de-alternaria-en-el-asma-infantil\/","title":{"rendered":"Repercusiones clinico-biologicas de un extracto oral de alternaria en el asma infantil"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angeles Criado Molina <\/strong><\/h2>\n<p>Debido a la controversia existente sobre la inmunoteriapo oral ( it oral), nos  planteamos la realizaci\u00f3n de un ensayo cl\u00ednico en 39 pacientes de 7 a 17 a\u00f1os  de edad, al\u00e9rgicos a alternaria, y sensibilizados a p\u00f3lenes y epitelios; con  el objetivo de valorar la eficacia de un extracto estandarizado de alternaria  administrado por v\u00eda oral y recoger la incidencia de reacciones adversas. La  actividades alerg\u00e9nicas del extracto se expres\u00f3 en pnu\/ml yla cuantificaci\u00f3n  del alergeno principal alt  1 fue de 34.2 ng\/g dde prote\u00edna. Los par\u00e1metros  analizados fueron score del s\u00edntoma y medicaci\u00f3n, prick test cut\u00e1neo punto  final alternaria, test de broncoprovocaci\u00f3n especifico ( tbpe), pico de flujo  (pf), ige total y especifica e igg4 espec\u00edfica.  diecis\u00e9is pacientes recibieron tratamiento activo con it oral y otro diecis\u00e9is  recibieron tratamiento m\u00e9dico exclusivamente. La fase de inicio de la it dur\u00f3  3 meses, hasta llegar a dosis m\u00e1xima, la cu\u00e1l se mantuvo durante 12 meses,  alcanzando una dosis acumulada media de 288.000 pnu, lo que corresponde a 3-4  veces la dosis utilizada en it subcut\u00e1nea.  se hallaron diferencias significativas en la disminuci\u00f3n del score de s\u00edntomas  medicaci\u00f3n en el grupo tratado, as\u00ed como en el score de s\u00edntomas analizado de  forma independiente tras 12 meses de it oral; no se encontraron diferencias en  el grupo control. Fue en general bien tolerada, present\u00e1ndose reacciones  adversas de car\u00e1cter leve-moderado exclusivamente. Se encontr\u00f3 una disminuci\u00f3n  significativa del tama\u00f1o de p\u00e1pula en el grupo tratado. Eltbpe expresado  mediante la pd20 mostr\u00f3 cifras significativamente m\u00e1s altas en el grupo con  it. El pico de flujo no mostr\u00f3 cambios en ninguno de los dos grupos. Los  valores de igg4 fueron significativamente m\u00e1s altos en el grupo con  tratamiento activo. Los valores de la ige total y espec\u00edfica no mostraron  cambios significativos en ambos grupos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Repercusiones clinico-biologicas de un extracto oral de alternaria en el asma infantil<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Repercusiones clinico-biologicas de un extracto oral de alternaria en el asma infantil <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angeles Criado Molina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Guerras Pasadas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li>Jos\u00e9 Conde hernandez (vocal)<\/li>\n<li> Arenas vacas Antonio  pablo (vocal)<\/li>\n<li>pedro Guardia Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angeles Criado Molina Debido a la controversia existente sobre la inmunoteriapo oral ( it oral), nos planteamos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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