{"id":81605,"date":"2018-03-10T00:05:30","date_gmt":"2018-03-10T00:05:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-neurotoxicidad-de-cilosporina-en-ratas\/"},"modified":"2018-03-10T00:05:30","modified_gmt":"2018-03-10T00:05:30","slug":"estudio-de-la-neurotoxicidad-de-cilosporina-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-neurotoxicidad-de-cilosporina-en-ratas\/","title":{"rendered":"Estudio de la neurotoxicidad de cilosporina en ratas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Blanco Reina <\/strong><\/h2>\n<p>El objetivo del presente trabajo es el estudio de la acci\u00f3n de la ciclosporina y su disolvente cremaphores, sobre el estatus oxidativo cerebral enc ondiciones in vitro y ex vivo, usando como animal experimental la rata.  los experimentos in vitro muestran que tanto la ciclosporina como su disolvente originan un incremento de la peroxidacci\u00f3n lip\u00eddica de membrana, as\u00ed como unfreno en el sistema antioxidante end\u00f3geno de glutation. En los modelos de producci\u00f3nd e radicales libres mediante la t\u00e9cnica de anoxia-reoxigenaci\u00f3n ambas sustancias no permiten que el tejido active sus defensas antioxidantes end\u00f3genas.  la adminsitraci\u00f3n por v\u00eda subcut\u00e1nea de los preparados solos o en combinaci\u00f3n en un modelo sucr\u00f3nico origina una disociaci\u00f3n del efecto prooxidante del f\u00e1rmaco, en comapraci\u00f3n con su disolvente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la neurotoxicidad de cilosporina en ratas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la neurotoxicidad de cilosporina en ratas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Blanco Reina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cruz Cortes Jos\u00e9 Pedro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Garcia morillas <\/li>\n<li>m isabel Lucena gonzalez (vocal)<\/li>\n<li>eduardo Navarro (vocal)<\/li>\n<li>pablo Salinas s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Blanco Reina El objetivo del presente trabajo es el estudio de la acci\u00f3n de la ciclosporina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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