{"id":81683,"date":"2018-03-10T00:05:33","date_gmt":"2018-03-10T00:05:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nous-esquemes-daadministracio-daun-derivat-de-la-camptotecina-associacio-in-vitro-amb-drogues-especa%c2%adfiques-del-cicle-cel-lular\/"},"modified":"2018-03-10T00:05:33","modified_gmt":"2018-03-10T00:05:33","slug":"nous-esquemes-daadministracio-daun-derivat-de-la-camptotecina-associacio-in-vitro-amb-drogues-especa%c2%adfiques-del-cicle-cel-lular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nous-esquemes-daadministracio-daun-derivat-de-la-camptotecina-associacio-in-vitro-amb-drogues-especa%c2%adfiques-del-cicle-cel-lular\/","title":{"rendered":"Nous esquemes d\u00c2\u00bfadministraci\u00f3 d\u00c2\u00bfun derivat de la camptotecina: associaci\u00f3 in vitro amb drogues espec\u00edfiques del cicle cel. lular"},"content":{"rendered":"

Tesis doctoral de Miguel Taron Roca <\/strong><\/h2>\n

La supervivencia de los enfermos con c\u00e1ncer colerectal (ccr) en estadio avanzado contin\u00faa siendo baja a pesar de la incorporaci\u00f3n de nuevos esquemas como la infusi\u00f3n continua de 5-fluorouracilo(5fu)\/lv y de la aparici\u00f3n de nuevos agentes activos en ccr con mecanismos de acci\u00f3n distintos al del 5fu, lo que ha permitido la incorporaci\u00f3n de reg\u00edmenes de polioquimioterapia. entre estos agentes cabe destacar el tomudex(tx) y los inhibidores de la camptotecina(cpt-11 y topotecan), todos ellos espec\u00edficos de fase s del ciclo celular. El objetivo del estudio es analizar en c\u00e9lulas derivadas de tumores colectores humanos(ht29 y lovo) cuales son los mejores esquemas de combinaci\u00f3n de los derivados de la camptotecina, el tx y el 5-fu para conseguir un m\u00e1ximo efecto citit\u00f3xico. Para ello se caracterizaron en primer lugar las perturbaciones de las fases del ciclo celular despu\u00e9s de una exposici\u00f3n corta a una dosis de tpt(20 o 60 minutos) buscando el mejor esquema para conseguir el m\u00e1ximo reclutamiento de c\u00e9lulas en fase s del ciclo. La administraci\u00f3n de tptx1um durante 20(ht29) o 60 (lo vo) minutos demostr\u00f3 reclutar un 43% o 29% m\u00e1s de celulas en fase s respecto de la poblaci\u00f3n control, 10 y 8 horas despu\u00e9s del tratamiento(ht29 y lo vo,respectivamente). una vez realizada la tipificaci\u00f3n se analiz\u00f3 la toxicidad de los esquemas secuenciales tpt->5fu(i),tpt->tx(ii),tpt->tpt(iii), donde la admnistraci\u00f3n del segundo agente se realiz\u00f3 en distintos intervalos correspondientes a diferentes proporciones de c\u00e9lulas en fase s inducidas por la primera exposici\u00f3n a tpt. Se analizaron tambi\u00e9n los esquemas inversos 5fu->tpt(iv),tx->tpt(v) y tpt en infusi\u00f3n(10 horas)(vi). Globalmente se observ\u00f3 un efecto antag\u00f3nico en todos los esquemas, excepto para tpt->tpt(iii) y 5fu->tpt(ht29) donde se obtuvo un efecto antag\u00f3nico en todos los esquemas, excepto para tpt->tpt(iii) y 5fu->tpt(ht29) donde se obtuvo un efecto de<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abNous esquemes d\u00c2\u00bfadministraci\u00f3 d\u00c2\u00bfun derivat de la camptotecina: associaci\u00f3 in vitro amb drogues espec\u00edfiques del cicle cel. lular<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Nous esquemes d\u00c2\u00bfadministraci\u00f3 d\u00c2\u00bfun derivat de la camptotecina: associaci\u00f3 in vitro amb drogues espec\u00edfiques del cicle cel. lular <\/li>\n
  • Autor:<\/strong>\u00a0 Miguel Taron Roca <\/li>\n
  • Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/1999<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Albert Abad Esteve<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Mar\u00eda no Monzo planello <\/li>\n
        • agust\u00ed Barnadas molins (vocal)<\/li>\n
        • Manuel Monreal bosch (vocal)<\/li>\n
        • Francisco xavier Real arribas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Miguel Taron Roca La supervivencia de los enfermos con c\u00e1ncer colerectal (ccr) en estadio avanzado contin\u00faa siendo […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,160,155,35,9,9399,561,347,17],"tags":[44049,58686,13679,14008,174164,155446],"class_list":["post-81683","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-bioquimica","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-cultivo-celular","category-farmacologia-molecular","category-oncologia-clinica","category-quimica","tag-agusti-barnadas-molins","tag-albert-abad-esteve","tag-francisco-xavier-real-arribas","tag-manuel-monreal-bosch","tag-maria-no-monzo-planello","tag-miguel-taron-roca"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=81683"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81683\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=81683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=81683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=81683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}