{"id":81725,"date":"2018-03-10T00:05:37","date_gmt":"2018-03-10T00:05:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-del-factor-nf-kb-por-tnf-durante-la-activacion-del-linfocito-t-bases-moleculares-de-la-activacion-de-c-rel\/"},"modified":"2018-03-10T00:05:37","modified_gmt":"2018-03-10T00:05:37","slug":"modulacion-del-factor-nf-kb-por-tnf-durante-la-activacion-del-linfocito-t-bases-moleculares-de-la-activacion-de-c-rel","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-del-factor-nf-kb-por-tnf-durante-la-activacion-del-linfocito-t-bases-moleculares-de-la-activacion-de-c-rel\/","title":{"rendered":"Modulacion del factor nf-kb por tnf durante la activacion del linfocito t. bases moleculares de la activacion de c-rel."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Garcia Martin <\/strong><\/h2>\n<p>Se ha estudiado el papel de la citoquina tnf sobre la activaci\u00f3n del linfocito t. Esta mediaci\u00f3n se produce a trav\u00e9s del factor nf-kb, siendo esencial la activaci\u00f3n de la prote\u00edna c-rel. Esta activaci\u00f3n se produce por la fosforilaci\u00f3n de su dominio de transactivaci\u00f3n, siendo esencial la fosforilaci\u00f3n del residuo de serina 471.  el dominio de transactivaci\u00f3n de c-rel se compone de dos regiones: la regi\u00f3n 540-588, necesaria para la actividad transcripcional y fuertemente fosforilada en condiciones basales; y la regi\u00f3n 422-540, donde residen las propiedades fosforilables. Son esenciales los residuos de serina 455, 461, 464, 470, 471 y 473. Por otro lado participa la fosforilaci\u00f3n de los residuos 492, 494, 509-512, 514 y 519, aunque esta fosforilaci\u00f3n no es esencial.  en la ruta de activaci\u00f3n de c-rel por tnf participan las prote\u00ednas pi3-k y pkcz, de modo que las dianas de actuaci\u00f3n de \u00e9sta \u00faltima son los residuos de serina 461 y 492-494, no obstante pkcz no fosforila directamente a c-rel.  por otra parte, la activaci\u00f3n de c-rel por tnf est\u00e1 implicada en mecanismos de supervivencia celular frente a la apoptosis inducida por el propio tnf.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion del factor nf-kb por tnf durante la activacion del linfocito t. bases moleculares de la activacion de c-rel.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion del factor nf-kb por tnf durante la activacion del linfocito t. bases moleculares de la activacion de c-rel. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Garcia Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Fresno Escudero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor menendez <\/li>\n<li>augusto Silva gonzalez (vocal)<\/li>\n<li>Jos\u00e9 Alcami pertejo (vocal)<\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Garcia Martin Se ha estudiado el papel de la citoquina tnf sobre la activaci\u00f3n del linfocito [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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