{"id":81729,"date":"2018-03-10T00:05:37","date_gmt":"2018-03-10T00:05:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-del-complejo-cadherina-e-cateninas-y-de-la-estabilidad-metabolica-de-la-b-catenina-por-el-oncogen-h-ras-y-su-efector-pi3k\/"},"modified":"2018-03-10T00:05:37","modified_gmt":"2018-03-10T00:05:37","slug":"modulacion-del-complejo-cadherina-e-cateninas-y-de-la-estabilidad-metabolica-de-la-b-catenina-por-el-oncogen-h-ras-y-su-efector-pi3k","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-del-complejo-cadherina-e-cateninas-y-de-la-estabilidad-metabolica-de-la-b-catenina-por-el-oncogen-h-ras-y-su-efector-pi3k\/","title":{"rendered":"Modulacion del complejo cadherina e\/cateninas y de la estabilidad metabolica de la b catenina por el oncogen h-ras y su efector pi3k"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Espada Regalado <\/strong><\/h2>\n<p>El complejo cacherina e\/cateninas se encuentra frecuentemente desorganizado en carcinomas, pero los mecanismos subyacentes a esta perdida funcional no estan bien caracterizados. Mas aun, la b catenina, es un componente del complejo achetina e\/cateninas que tambien particia en la transduccion de la se\u00f1al de wnt, que esta alterada en muchas lineas celulares tumorales y canceres humanos. Ademas, la activacion del oncogen h-ras es un suceso temprano en la progresion tumoral durante la carcinogenesis en piel de raton. En este contexto, el efecto de la activacion oncog\u00e9nica de h-ras se ha estudiado en queratinocitos epidermicos murinos, utilizando una combinacion de tecnicas de microinyecci\u00f3n de h-v12ras y analisis bioquimico de queratinocitos que expresan establemente h-v12ras.  la microinyeccion de h-v12ras en queratinocitos murinos promueve la perdida de cadherina e y a catenina de las regiones de contacto celula-celula y la relocalizaci\u00f3n citoplasm\u00e1tica y nuclear de la bcatenina. Estos efectos dependen de la actividad dela pi3k. En el mismo sentido, la expresi\u00f3n de h-v12ras en queratinocitos induce la solubilizaci\u00f3n de los componentes del completo cadherina e\/cateninas, aunque sin alterar el contenido de p-tyr de estas proteinas.  interesantemente, existe una interaccion \u00abin vivo\u00bb de la b catenina con las dos subunidades de la pi13k, p85a y p110a, fuertemente inducida por la sobreexpresi\u00f3n de h-v12ras, asi como una interaccion directa \u00abin vitro\u00bb de la b catenina con la p85a. Mas aun, la sobreexprsion tanto de h-v12ras como de una forma constitutivamente de la p13k es suficiente para estabilizar metab\u00f3licamente a la b catenina y promover su acumulacion citoplasmatica y nuclear.  la fosforilacion \u00abin vivo\u00bb de la b catenina esta fuertemente disminuida en queratinocitos que expresan h-v12ras, afectando fundamentalmente el contenido en p-ser. Ademas, la interaccion de la b catenina con la proteina apc esta bloqueada en celulas que ex<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion del complejo cadherina e\/cateninas y de la estabilidad metabolica de la b catenina por el oncogen h-ras y su efector pi3k<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion del complejo cadherina e\/cateninas y de la estabilidad metabolica de la b catenina por el oncogen h-ras y su efector pi3k <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Espada Regalado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amparo Cano Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: senen Vilar\u00f3 coma <\/li>\n<li>angels Fabra fres (vocal)<\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li>piero Crespo baaraja (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Espada Regalado El complejo cacherina e\/cateninas se encuentra frecuentemente desorganizado en carcinomas, pero los mecanismos subyacentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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