{"id":81760,"date":"2018-03-10T00:05:41","date_gmt":"2018-03-10T00:05:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-ur-12746-en-un-modelo-experimental-de-inflamacion-intestinal-en-ratas\/"},"modified":"2018-03-10T00:05:41","modified_gmt":"2018-03-10T00:05:41","slug":"estudio-del-efecto-de-ur-12746-en-un-modelo-experimental-de-inflamacion-intestinal-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-de-ur-12746-en-un-modelo-experimental-de-inflamacion-intestinal-en-ratas\/","title":{"rendered":"Estudio del efecto de ur-12746 en un modelo experimental de inflamacion intestinal en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Margarita Garrido Siles <\/strong><\/h2>\n<p>El objetivo de la presente tesis doctoral fue investigar el efecto antiinflamatorio intestinal de el ur-12746 en un modelo experimental de colitis en ratas (modelo del tnbs). Ur-12746 es un compuesto que combina meidante un enlace azo el \u00e1cido 5-aminosalic\u00edlico y ur-12715 un antagonista del baf. El tratamiento oral conur-12746 a las dosis de 50 y 100 miligramos\/kg redujo el da\u00f1o col\u00f3nico en las fases aguda y cr\u00f3nica que caracterizan el modelo de colitis en ratas.  el efecto antiinflamatorio intestinal del compuesto se puso de manifiesto por una dimsinuci\u00f3n de la infliltraci\u00f3n leucocitaria de la mucosa col\u00f3nica, siendo superior a la mostrada por la sulfasalacina, f\u00e1rmaco utilizado como control. Distintos mecanismos pueden estar relacionados con el efecto beneficioso manifestado por ur-12746: inhibici\u00f3n de la s\u00edntesisi de leucotrieno b4 en el colon inflamado, mejora del estado oxidativo col\u00f3nico alterado y reducci\u00f3n en la producci\u00f3n de citoquinas pronflamqtorias como interluquina-1 y tnf.  estos resultados sugieren que la actividad antiinflamatoria intesinal de ur-12746 se pueden relaci\u00f3n con la suma de los efectos ejercidos por el \u00e1cido 5-aminosalic\u00f3lico y el compuesto antagonista del paf, ur-12715, que se liberan en la luza del colon tras la reducci\u00f3n del enlace azo por las bacterias intestinales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto de ur-12746 en un modelo experimental de inflamacion intestinal en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto de ur-12746 en un modelo experimental de inflamacion intestinal en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Margarita Garrido Siles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zarzuelo Zurita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Jim\u00e9nez mart\u00edn <\/li>\n<li>Javier Forn dalmau (vocal)<\/li>\n<li> Gassull i duro Miguel angel (vocal)<\/li>\n<li>vicente Esplugues Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Margarita Garrido Siles El objetivo de la presente tesis doctoral fue investigar el efecto antiinflamatorio intestinal de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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