{"id":81783,"date":"2018-03-10T00:05:41","date_gmt":"2018-03-10T00:05:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-experimental-de-derivados-y-analogos-de-heterobenzotiazepinas-con-potencial-accion-antidepresiva\/"},"modified":"2018-03-10T00:05:41","modified_gmt":"2018-03-10T00:05:41","slug":"estudio-farmacologico-experimental-de-derivados-y-analogos-de-heterobenzotiazepinas-con-potencial-accion-antidepresiva","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-experimental-de-derivados-y-analogos-de-heterobenzotiazepinas-con-potencial-accion-antidepresiva\/","title":{"rendered":"\u00abestudio farmacologico experimental de derivados y analogos de heterobenzotiazepinas con potencial accion antidepresiva\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Albertos Garcia Luz M. <\/strong><\/h2>\n<p>Los compuestos en estudio se sometieron a una serie de tests generales de psicofarmacolog\u00eda, as\u00ed como a tests espec\u00edficos para determinar su posible actividad antidepresiva, analg\u00e9sica y antiinflamatoria. Merece resaltar en esta tesis su gran faceta formativa dada la amplia serie de t\u00e9cnicas experimentales empleadas.  tras los resultados obtenidos podemos comentar que, en general, la mayor\u00eda de los compuestos ensayados ejercieron a 100 mg\/kg p.O. Efectos depresores de actividad motora y exploratoria, un efecto hipotermizante as\u00ed como un incremento significativo del sue\u00f1o inducido por dosis hipn\u00f3ticas de pentobarbital s\u00f3dico. Por lo que se refiere a la actividad antidepresiva, varios de los compuestos ensayados mostraron una actividad interesante, destacando en este sentido el it10, que result\u00f3 activo en cuatro de la tesis pruebas realizadas para evaluar dicha actividad, presentando valores pr\u00f3ximos a los antidepresivos de referencia en el test de porsolt. Por su parte los productos it9 e it46, aunque s\u00f3lo fueron activos en dos de la seis pruebas realizadas, presentaron tambi\u00e9n en el test de porsolt, valores similares a los antidepresivos de referencia. Por \u00faltimo, hay que resaltar que la mayor\u00eda de los compuestos mostraron una interesante actividad analg\u00e9sica y antiinflamatoria a nivel t\u00f3pico y algunos de ellos una acci\u00f3n ansiol\u00edtica y neurol\u00e9ptica, siendo interesante continuar los estudios en este campo para perfilar mejor su actividad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abestudio farmacologico experimental de derivados y analogos de heterobenzotiazepinas con potencial accion antidepresiva\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abestudio farmacologico experimental de derivados y analogos de heterobenzotiazepinas con potencial accion antidepresiva\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Albertos Garcia Luz M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victoriano Darias Del Castillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Fernandez caldas <\/li>\n<li>salvador Vega noverola (vocal)<\/li>\n<li>leocadio Rodr\u00edguez \u00e1lvarez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Albertos Garcia Luz M. Los compuestos en estudio se sometieron a una serie de tests generales de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,183,9915,7464,324],"tags":[174335,37189,34034,6642,17531],"class_list":["post-81783","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-psicotropicos","category-la-laguna","category-psicofarmacologia","category-psicologia","tag-albertos-garcia-luz-m","tag-enrique-fernandez-caldas","tag-leocadio-rodriguez-alvarez","tag-salvador-vega-noverola","tag-victoriano-darias-del-castillo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=81783"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81783\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=81783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=81783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=81783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}