{"id":81905,"date":"2018-03-10T00:05:50","date_gmt":"2018-03-10T00:05:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunofenotipado-de-sindromes-linfoproliferativos-cronicos\/"},"modified":"2018-03-10T00:05:50","modified_gmt":"2018-03-10T00:05:50","slug":"inmunofenotipado-de-sindromes-linfoproliferativos-cronicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/inmunofenotipado-de-sindromes-linfoproliferativos-cronicos\/","title":{"rendered":"Inmunofenotipado de sindromes linfoproliferativos cr\u00f3nicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Miguel Bergua Burgu\u00e9s <\/strong><\/h2>\n<p>Los s\u00edndromes linfoproliferativos cr\u00f3nicos son enfermedades malignas del sistema inmune caracterizadas por su monoclonalidad. Hemos estudiado 75 pacientes afectos de s\u00edndromes linfoproliferativos. El 61% de los casos estaban afectos de llc; un 10% de llc\/pl; 5 casos de linfoma espl\u00e9nico velloso, 5 leucemia linfocitos grandes granulares, 5 linfoma linfoplasmacitoide, 3 casos de linfoma del manto. Casos aislados de tricoleucemia, tricoleucemia variante, linfoma folicular y leucemia prolinfoc\u00edtica t. Hemos analizado el fenotipo de todos ellos por el cit\u00f3metro de flujo epics-xl. Se han analizado la expresi\u00f3n de los distintos marcadores como cd5, cd23, cd24, cd22, cd10, cd11c, cd103, fmc7, cd25, expresi\u00f3n de inmunoglobulinas de superficie. hemos comparado el score de matutes con nuestra casu\u00edstica. Se ha analizado las caracteriticas de s\u00edndromes linfoproliferativos t. Se han analizado las caracter\u00edsticas de expresi\u00f3n de prote\u00ednas intracitoplasm\u00e1ticas del tipo pcna, ki-67, bcl12, p53.  hemos encontrado que la expresi\u00f3n de cd19\/cd5+ es caracter\u00edstico de llc, llc\/pl, y linfoma del manto. Cd23 es espec\u00edfico de llc \u00f3 llc\/pl. Cd103 es caracter\u00edstico y \u00fanicamente expresado por el \u00fanico caso de tricoleucemia. bcl2 se expresa en todos los tipos de s\u00edndromes linfoproliferativos cr\u00f3nicos b, y nada en los casos de leucemia de linfocitos grandes granulares. Pcna se expresa en los casos de llc \u00f3 llc\/pl indicando la fase temprana de g1.P53 apenas se expresa en los casos de s\u00edndromes linfoproliferativos cr\u00f3nicos, no pareciendo existir mutaciones que permitan la sobreexpresi\u00f3n de p53. la expresi\u00f3n de ki-67 difiere expectacularmente de la referida en la literatura por inmunohistoqu\u00edmica, posiblemente debido a la mayor sensibilidad de la t\u00e9cnica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunofenotipado de sindromes linfoproliferativos cr\u00f3nicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunofenotipado de sindromes linfoproliferativos cr\u00f3nicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Miguel Bergua Burgu\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Larraz Mur<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: martin Gutierrez martin <\/li>\n<li>Luis Fern\u00e1ndez pereira (vocal)<\/li>\n<li>Emilio Doblar\u00e9 castellano (vocal)<\/li>\n<li>Manuel Giralt raichs (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Miguel Bergua Burgu\u00e9s Los s\u00edndromes linfoproliferativos cr\u00f3nicos son enfermedades malignas del sistema inmune caracterizadas por su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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