{"id":81952,"date":"2018-03-10T00:05:55","date_gmt":"2018-03-10T00:05:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-diversos-farmacos-en-la-incorporacion-de-ofloxacino-y-grepafloxacino-al-interior-de-leucocitos-polimorfonucleares-humanos\/"},"modified":"2018-03-10T00:05:55","modified_gmt":"2018-03-10T00:05:55","slug":"influencia-de-diversos-farmacos-en-la-incorporacion-de-ofloxacino-y-grepafloxacino-al-interior-de-leucocitos-polimorfonucleares-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-diversos-farmacos-en-la-incorporacion-de-ofloxacino-y-grepafloxacino-al-interior-de-leucocitos-polimorfonucleares-humanos\/","title":{"rendered":"Influencia de diversos farmacos en la incorporacion de ofloxacino y grepafloxacino al interior de leucocitos polimorfonucleares humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Orero Clavero <\/strong><\/h2>\n<p>Los leucocitos polimorfonucleares(pmn) son c\u00e9lulas especialidades en la defensa del organismo frente a las infecciones. La mayor\u00eda de microoganismos son sensibles a este sistema de defensa celular, pero determinadas bacterias son capaces de vivir en el interior de leucocitos, de forma facultativa y obligatoria, eludiendo los mecanismos bactericidas de los mismos y convirtiendo a estas c\u00e9lulas en un reservatorio de microorganismos que producen nuevos brotes infecciosos.  tambien existen pacientes cuyos leucocitos tienen mermadas sus funciones bactericidas, bien por un deficiencias genetica o bien por estad de inmunodepresi\u00f3n, que puede ser patolog\u00eda, fisiol\u00f3gica o provocada. En todos estos casos, esta deteriorada la primera linea de defensa celular, y el paciente es m\u00e1s propenso a adquirir infeciones, tanto por pat\u00f3genos habituales, como por los denominados pat\u00f3genos oportunistas. En las infecciones producidas por microorganismos intracelulares, y en el grupo de pacientes antes citado, es fundamental que el antibi\u00f3tico empleado sea capaz de penetrar en el interior de los leucocitos y ser activo frente a las bacterias localizadas en el ambiente intracelular.  el objetivo de este trabajo de investigaci\u00f3n es estudiar la interacci\u00f3n farmacocin\u00e9tica de determinados grupos de f\u00e1rmacos(antivirales, antiinflamatorios, antif\u00fangicos e inhibidores de bombas) en el paso y acumulaci\u00f3n de ofloxacino y grepafloxacino al interior de los leucocitos pmn, en dos condiciones experimentales diferentes, que reflejan dos posibles situaciones terap\u00e9uticas: el farmaco y la quinolona administrados simultaneamente o sucesivamente, que en nuestras condiciones experimentales lo expresamos como un tratamiento previo de los pmn con el farmaco y posterior adici\u00f3n de la quinolona. Como paso previo el estudio de la posible interaci\u00f3n farmacol\u00f3gico, caracterizamos la cin\u00e9tica de incorporaci\u00f3n de ambas quinolonas en nuestras condiciones de ensayo. Las c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de diversos farmacos en la incorporacion de ofloxacino y grepafloxacino al interior de leucocitos polimorfonucleares humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de diversos farmacos en la incorporacion de ofloxacino y grepafloxacino al interior de leucocitos polimorfonucleares humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Orero Clavero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Bermejo Sanz M. Val<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>isabel Garcia luque (vocal)<\/li>\n<li>Jos\u00e9 pedro Martinez garcia (vocal)<\/li>\n<li>Javier Peman garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Orero Clavero Los leucocitos polimorfonucleares(pmn) son c\u00e9lulas especialidades en la defensa del organismo frente a las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189],"tags":[174599,45345,42835,48398,1259,3474],"class_list":["post-81952","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","tag-ana-orero-clavero","tag-bermejo-sanz-m-val","tag-isabel-garcia-luque","tag-javier-peman-garcia","tag-jose-pedro-Martinez-garcia","tag-jose-prieto-prieto"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=81952"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81952\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=81952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=81952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=81952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}