{"id":81960,"date":"2018-03-10T00:05:55","date_gmt":"2018-03-10T00:05:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/xantina-oxidoreductasa-consideraciones-metodologicas-y-implicacion-en-la-lesion-por-isquemia-reperfusion-hepatica\/"},"modified":"2018-03-10T00:05:55","modified_gmt":"2018-03-10T00:05:55","slug":"xantina-oxidoreductasa-consideraciones-metodologicas-y-implicacion-en-la-lesion-por-isquemia-reperfusion-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/xantina-oxidoreductasa-consideraciones-metodologicas-y-implicacion-en-la-lesion-por-isquemia-reperfusion-hepatica\/","title":{"rendered":"Xantina oxidoreductasa: consideraciones, metodologicas y implicacion en la lesion por isquemia-reperfusion hepatica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ram\u00f3n Mart\u00ed Seves <\/strong><\/h2>\n<p>En este trabajo se ha puesto el metodo para la determinaci\u00f3n de las formas de la xantina oxidoreductasa(xor), es decir, xantina deshidrogenasa(xd) y xantina oxidasa(xo), en sus formas reversible e irreversible(xo rev y xo irr respectivamente),en sangre y en tejido hep\u00e1tico. Tambi\u00e9n se ha estudiado la implicaci\u00f3n de la enzima en la lesi\u00f3n de preservaci\u00f3n del trasplante hep\u00e1tico, en relaci\u00f3n con la lesi\u00f3n hepatocelular, lesi\u00f3n y funci\u00f3n endotelial del injerto, activaci\u00f3n neutrofilica y la administraci\u00f3n intraportal de prostaglandina e1(pge1).  hemos establecido la necesidad de eliminar del medio de reacci\u00f3n anal\u00edtica los productos per\u00f3xido y super\u00f3xido, as\u00ed como nadh, para evitar infravaloraciones debidas a inhibici\u00f3n por productos, cuando la enzima se determina por seguimiento, o a punto final, de la aparici\u00f3n de \u00e1cido urico. Tambi\u00e9n hemos observado la necesidad de utilizar periodos cortos de incubaci\u00f3n. Es trasplante hep\u00e1tico experimental porcino no hemos observado conversi\u00f3n de la forma xd en xo en el tejido debida a la preservaci\u00f3n soluci\u00f3n de preservaci\u00f3n de la universidad de wisconsin(uw), y descendente para soluci\u00f3n euro-collins(ec), durante el periodo pos-reperfusi\u00f3n del injerto. La lesi\u00f3n hepatocular es superior para per\u00edodos largos de preservaci\u00f3n y para la preservaci\u00f3n con ec, comparada con uw. La funci\u00f3n endotelial, en cambio, muestra una tendencia a recuperarse m\u00e1s rapidamente para ec que con uw.  el estudio de 20 transplantes hep\u00e1ticos humanos puso de manifiesto que la xor circulante es de origen exclusivamente hep\u00e1tico, y los resultados sugieren que la enzima se libera mayoritariamente  de los hepatocitos. existe una conversi\u00f3n de la forma xd,mayoritariamente en xo rev, despues de su liberaci\u00f3n. La xor, y su forma xoirr, determinadas en la sangre procedente del lavado del injerto en el momento de la reperfusi\u00f3n portal, muestran diferencias significativas entre dos grupos de pacientes c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Xantina oxidoreductasa: consideraciones, metodologicas y implicacion en la lesion por isquemia-reperfusion hepatica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Xantina oxidoreductasa: consideraciones, metodologicas y implicacion en la lesion por isquemia-reperfusion hepatica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ram\u00f3n Mart\u00ed Seves <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa Segura Cardona<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Gonz\u00e1lez sastre <\/li>\n<li>Rafael Franco fernandez (vocal)<\/li>\n<li>rossend Jardi margalef (vocal)<\/li>\n<li>lLuis Grande posa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ram\u00f3n Mart\u00ed Seves En este trabajo se ha puesto el metodo para la determinaci\u00f3n de las formas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,955,17,3665],"tags":[13646,47194,34019,143098,29248,174613],"class_list":["post-81960","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-enzimologia","category-quimica","category-quimica-clinica","tag-francesc-gonzalez-sastre","tag-lluis-grande-posa","tag-rafael-franco-fernandez","tag-ramon-marti-seves","tag-rosa-segura-cardona","tag-rossend-jardi-margalef"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=81960"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/81960\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=81960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=81960"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=81960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}