{"id":81996,"date":"2018-03-10T00:05:59","date_gmt":"2018-03-10T00:05:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-inmunologicas-en-cirugia-cardiaca-con-circulacion-extracorporea\/"},"modified":"2018-03-10T00:05:59","modified_gmt":"2018-03-10T00:05:59","slug":"alteraciones-inmunologicas-en-cirugia-cardiaca-con-circulacion-extracorporea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-inmunologicas-en-cirugia-cardiaca-con-circulacion-extracorporea\/","title":{"rendered":"Alteraciones inmunologicas en cirugia cardiaca con circulacion extracorporea"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael U\u00f1a Orejon <\/strong><\/h2>\n<p>La utilizacion de circuitos artificiales de derivacion cardiopulmonar se utilizo por primera vez en clinica en el a\u00f1o 1953. Aunque estos circuitos facilitan las tecnicas quirurgicas realizadas sobre el corazon y grandes vasos sin embargo, producen tambien una alteracion importante de las sistemas normales de homeostasis del organismo. El sistema inmunologico no puede estar exento a estas alteraciones, debido al contacto de las celulas inmunocompetentes con las paredes del sistema artificial de derivacion.  observamos que tras la realizacion de este tipo de cirugia se produce con frecuencia cuadros de insuficiencia respiratoria, insuficiencia renal e infecciones postoperatorias. Para valorar la respuesta inmunologica estudiamos 24 pacientes en los que realizamos recuento de leucocitos, plaquetas, inmunoglobulinas y activacion del complemento, ya fuese por la via alterna (fb y c3) o via clasica (c2 activado\/c2 nativo), en 8 momentos de la cirugia que consideramos prospectivamente significativo.  encontramos que se produce una leucopenia estadisticamente significativa, durante la fase de derivacion, seguida por una leucocitosis al finalizar este periodo. Tambien observamos, que aunque se produce una disminucion en el numero relativo de plaquetas e inmunoglobulinas, sin embargo no alcanza significacion estadistica cuando aplicamos un factor de correccion para la hemodilucion secundaria al cebado de la bomba. En cuanto a los factores del complemento se produce una activacion por via clasica coincidiendo con la administracion de la protamina utilizada para revertir la heparina, dicha activacion se atenua con la administracion de protamina previa a la heparina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones inmunologicas en cirugia cardiaca con circulacion extracorporea<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones inmunologicas en cirugia cardiaca con circulacion extracorporea <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael U\u00f1a Orejon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Criado Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Cuenca fernandez <\/li>\n<li>Luis Garcia sancho (vocal)<\/li>\n<li>Juan Navia roque (vocal)<\/li>\n<li>Fernando Noguerales fraguas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael U\u00f1a Orejon La utilizacion de circuitos artificiales de derivacion cardiopulmonar se utilizo por primera vez en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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