{"id":82143,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/intoxicaciones-cocainicas-aspectos-analiticos-y-toxicologicos\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"intoxicaciones-cocainicas-aspectos-analiticos-y-toxicologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/intoxicaciones-cocainicas-aspectos-analiticos-y-toxicologicos\/","title":{"rendered":"Intoxicaciones cocainicas. aspectos analiticos y toxicologicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Bujan De Gonzalo Laura <\/strong><\/h2>\n<p>La extensi\u00f3n del consumo de coca\u00edna ha provocado el desarrollo de distintos procedimientos anal\u00edticos para determinar, no solo el alcaloide, sino tambi\u00e9n sus principales metabolitos, benzoilecgonina y ecgoninametl\u00e9ster. los m\u00e9todos cromatogr\u00e1ficos permiten confirmar los resultados iniciales obtenidos por t\u00e9cnicas r\u00e1pidas de screening de drogas. Por ello, los objetivos de esta memoria han sido: desarrollar dos m\u00e9todos para la identificaci\u00f3n y cuantificaci\u00f3n de coca\u00edna y sus metabolitos, en orina y sangre, utilizando cromatograf\u00eda de gases (gc) con detector de ionizaci\u00f3n de llama y cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n (hplc) con detector ultavioleta; y, aplicar dichos m\u00e9todos al estudio de intoxicaciones coca\u00ednicas reales.  el proceso comenz\u00f3 con un paso previo de extracci\u00f3n s\u00f3lido-l\u00edquido, llevado a cabo con columnas bond elut certify. Y, una vez establecidas las condiciones cromatogr\u00e1ficas m\u00e1s adecuadas en las dos t\u00e9cnicas, partiendo de una serie de disoluciones de concentraci\u00f3n conocida de coca\u00edna y sus metabolitos, se construyeron las rectas de calibrado mediante el m\u00e9todo de ajuste de m\u00ednimos biol\u00f3gicos estudiados. Se determin\u00f3: 1.- La linealidad de ambos m\u00e9todos, calculando los coeficientes de correlaci\u00f3n de las rectas y los l\u00edmites de confianza de la pendiente y del t\u00e9rmino independiente, 2.- La sensibilidad, mediante el l\u00edmite de detecci\u00f3n y el limite de cuantificaci\u00f3n, 3.- La precisi\u00f3n, en base a los coeficientes de variaci\u00f3n, 4.- La exactitud, como porcentaje de la diferencia entre el valor hallado y el valor verdadero, y 5.- El rendimiento de la extracci\u00f3n.  los dos m\u00e9todos propuestos se aplicaron al an\u00e1lisis de muestras de orina y sangre de sujetos vivos consumidores de coca\u00edna, y material postmortem procedente de individuos que fallecieron como consecuencia de la administraci\u00f3n de coca\u00edna sola o combinada con otras drogas de abuso, encontr\u00e1ndose una buena con<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Intoxicaciones cocainicas. aspectos analiticos y toxicologicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Intoxicaciones cocainicas. aspectos analiticos y toxicologicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Bujan De Gonzalo Laura <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Purificacion Fernandez Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Lopez rivadulla lamas <\/li>\n<li> Camean fernandez Ana Mar\u00eda (vocal)<\/li>\n<li>angel Concheiro nine (vocal)<\/li>\n<li>Mar\u00eda  isabel Arufe Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bujan De Gonzalo Laura La extensi\u00f3n del consumo de coca\u00edna ha provocado el desarrollo de distintos procedimientos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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