{"id":82230,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-forma-y-tamano-de-proteinas-en-disolucion-mediante-dispersion-de-rayos-x-y-algoritmos-geneticos\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"determinacion-de-forma-y-tamano-de-proteinas-en-disolucion-mediante-dispersion-de-rayos-x-y-algoritmos-geneticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/determinacion-de-forma-y-tamano-de-proteinas-en-disolucion-mediante-dispersion-de-rayos-x-y-algoritmos-geneticos\/","title":{"rendered":"Determinacion de forma y tama\u00f1o de proteinas en disolucion mediante dispersion de rayos-x y algoritmos geneticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Chacon Montes <\/strong><\/h2>\n<p>Este trabajo consiste en el desarrollo y aplicaci\u00f3n experimental de un m\u00e9todo basado en una combinaci\u00f3n de c\u00e1lculo de debye y algoritmos gen\u00e9ticos, que permite resolver num\u00e9ricamente el problema inverso de la dispersi\u00f3n de rayos-x, es decir, deducir ab initio la forma y dimensiones de macromol\u00e9culas en disoluci\u00f3n a partir de su perfil de dispersi\u00f3n. este algoritmo genera eficazmente modelos estructurales (formados por varios cientos de esferas id\u00e9nticas) cuyos perfiles de dispersi\u00f3n se ajustan a un determinado perfil problema. los modelos obtenidos con perfiles te\u00f3ricos calculados a partir de estructuras cristalogr\u00e1ficas son convergentes y reproducen las estructuras problema, a la resoluci\u00f3n del modelo. Aplicando el m\u00e9todo a los perfiles experimentales de dispersi\u00f3n de rayos-x de nueve prote\u00ednas a 2 nm resoluci\u00f3n, se han obtenido en todos los casos modelos convergentes hacia una determinada forma y cuyos perfiles son superponibles con los experimentales. estos modelos son generalmente compatibles con las correspondientes estructuras cristalinas, lo que valida la aplicabilidad del m\u00e9todo. El n\u00famero de esferas de cada modelo est\u00e1 correlacionado con la masa molecular de cada prote\u00edna. Se ha predicho la forma de tres prote\u00ednas de estructura cristalogr\u00e1fica desconocida y se ha explorado la determinaci\u00f3n de cambios estructurales en disoluci\u00f3n.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinacion de forma y tama\u00f1o de proteinas en disolucion mediante dispersion de rayos-x y algoritmos geneticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinacion de forma y tama\u00f1o de proteinas en disolucion mediante dispersion de rayos-x y algoritmos geneticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Chacon Montes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico Mor\u00e1n Abad<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Montero carnerero <\/li>\n<li>federico Gago badenas (vocal)<\/li>\n<li>Jos\u00e9 Lopez carrascosa (vocal)<\/li>\n<li>ignacio Fita rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Chacon Montes Este trabajo consiste en el desarrollo y aplicaci\u00f3n experimental de un m\u00e9todo basado en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,3178,17],"tags":[30211,4797,4798,15733,21426,168009],"class_list":["post-82230","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-proteinas","category-quimica","tag-federico-gago-badenas","tag-federico-moran-abad","tag-francisco-montero-carnerero","tag-ignacio-fita-rodriguez","tag-jose-lopez-carrascosa","tag-pablo-chacon-montes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=82230"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82230\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=82230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=82230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=82230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}