{"id":82262,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-marcadores-de-proliferacion-y-diferenciacion-celular-en-los-astrocitomas-malignos-supratentoriales\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"estudio-de-los-marcadores-de-proliferacion-y-diferenciacion-celular-en-los-astrocitomas-malignos-supratentoriales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-los-marcadores-de-proliferacion-y-diferenciacion-celular-en-los-astrocitomas-malignos-supratentoriales\/","title":{"rendered":"Estudio de los marcadores de proliferacion y diferenciacion celular en los astrocitomas malignos supratentoriales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Jimenez Arrosaca <\/strong><\/h2>\n<p>La demostraci\u00f3n de la naturaleza astroc\u00edtica del gliobastoma ha planteado un problema de diagn\u00f3stico diferencial con el astrocitoma anapl\u00e1sico, dada la dificultad en poder objetivar niveles de anaplasia que los diferencie. La oms. Asigna el grado iv al glioblastoma y el grado iii al astrocitoma anapl\u00e1sico, seg\u00fan se observe o no en el tumor necrosis y\/o proliferaci\u00f3n microvascular. pero este sistema no establece una clara diferencia pron\u00f3stica entre estos dos grupos (grados); produci\u00e9ndose un importante solapamiento de casos en relaci\u00f3n a la supervivencia observada, entre los dos grupos as\u00ed definidos.  de ah\u00ed nuestro planteamiento en la utilizaci\u00f3n de marcadores celulares de proliferaci\u00f3n (expresi\u00f3n de la prote\u00edna ki-67) y diferenciaci\u00f3n astroc\u00edtica (expresi\u00f3n de la prote\u00edna gfap) para establecer niveles de anaplasia con diferente pron\u00f3stico (\u00abgrados histol\u00f3gicos\u00bb), que sean reprodubles objetivamente.#  para ello hemos estudiado la supervivencia de 81 pacientes con astrocitomas de grados iii y iv (oms) y las variables clinicopatol\u00f3gicas que pudieran guardar relaci\u00f3n con ella. Encontrando significaci\u00f3n pron\u00f3stica en la edad, sexo, necrosis, angiog\u00e9nesis, ki-67 y gfap; mostrando estas dos \u00faltimas variables significaci\u00f3n pron\u00f3stica independiente en el an\u00e1lisis multivariante.  hemos construido un modelo basado en la expresi\u00f3n de estos marcadores celulares; de manera que los pacientes con tumor que expresa un alto contenido en gfap y bajo \u00edndice proliferativo (ki-67) muestran significativamente mayor supervivencia que los de elevada actividad proliferativa y bajo contenido en gliofilamentos (gfap); encontr\u00e1ndose en relaci\u00f3n inversa estas dos variables .  la capacidad discriminante de este sistema es superior a la aplicaci\u00f3n de necrosis y\/o angiog\u00e9nesis, con un 77% frente a un 59% de casos correctamente clasificados, seg\u00fan el tiempo de supervivencia observado respectodel esperado.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los marcadores de proliferacion y diferenciacion celular en los astrocitomas malignos supratentoriales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los marcadores de proliferacion y diferenciacion celular en los astrocitomas malignos supratentoriales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Jimenez Arrosaca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santiago Coca Menchero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julian Sanz espovera <\/li>\n<li>Jes\u00fas Vaquero crespo (vocal)<\/li>\n<li>Santiago Ramon y cajal ag\u00ed\u00bceras (vocal)<\/li>\n<li>julia Bujan varela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Jimenez Arrosaca La demostraci\u00f3n de la naturaleza astroc\u00edtica del gliobastoma ha planteado un problema de diagn\u00f3stico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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