{"id":82269,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-interleuquina-6-secretada-por-las-celulas-endoteliales-inhibe-la-apoptosis-in-vitro-de-la-leucemia-linfocitica-b\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"la-interleuquina-6-secretada-por-las-celulas-endoteliales-inhibe-la-apoptosis-in-vitro-de-la-leucemia-linfocitica-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-interleuquina-6-secretada-por-las-celulas-endoteliales-inhibe-la-apoptosis-in-vitro-de-la-leucemia-linfocitica-b\/","title":{"rendered":"La interleuquina 6 secretada por las celulas endoteliales inhibe la apoptosis \u00abin vitro\u00bb de la leucemia linfocitica b."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Moreno Cerro Ana M. <\/strong><\/h2>\n<p>Son caracter\u00edsticas fundamentales de la leucemia linfoc\u00edtica cr\u00f3nica b (llc-b): 1) la acumulaci\u00f3n en diversos territorios del organismo de un \u00abpool\u00bb de linfocitos b neopl\u00e1sicos cd5+, con una vida media aumentada y, parad\u00f3jicamente, 2) una muerte r\u00e1pida por apoptosis \u00abin vitro\u00bb. estas diferencias en la muerte celular \u00abin vivo\u00bb e \u00abin vitro\u00bb podr\u00edan ser debidas a la ausencia de ciertos est\u00edmulos inhibidores de apoptosis cuando las c\u00e9lulas son cultivadas \u00abin vitro\u00bb que, sin embargo, estar\u00edan presentes \u00abin vivo\u00bb. Estos est\u00edmulos podr\u00edan proceder de c\u00e9lulas capaces de interaccionar con las c\u00e9lulas leuc\u00e9micas, como por ejemplo, las c\u00e9lulas endoteliales (ces). los resultados m\u00e1s destacados del presentes estudio son: 1) el medio condicionado (m.Cd) procedente de las ces inhibe la apoptosis espont\u00e1nea \u00abin vitro\u00bb de las c\u00e9lulas de la llc-b, lo que ha sido confirmado por diferentes m\u00e9todos. 2) en los cultivos de ces\/llc-b, impidiendo el contacto directo mediante c\u00e1maras \u00abtranswell\u00bb, la viabilidad de las c\u00e9lulas leuc\u00e9micas se mantiene durante m\u00e1s tiempo que en m.Cd. 3) el efecto anti-apopt\u00f3tico mediado por contacto entre ce\/c\u00e9lula leuc\u00e9mica es irrelevante. 4) la se\u00f1al anti-apopt\u00f3tica medida por el m.Cd de la ce no induce proliferaci\u00f3n ni diferenciaci\u00f3n de la c\u00e9lula tumoral. 5) la actividad promotora de supervivencia del m.Cd de la ce es espec\u00edfica para las c\u00e9lulas de la llc-b. 6) el factor soluble inhibidor de la apoptosis contenido en el m.Cd es il-6 con un peso molecular de 40-60 kda. 7) las c\u00e9lulas de la llc-b expresan el receptor de il-6 (cd126). 8) las prote\u00ednas bcl-2 y bax de la c\u00e9lula de la llc-b no est\u00e1n implicadas directamente en el efecto antiapopt\u00f3tico de la il-6 producida por el endotelio.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La interleuquina 6 secretada por las celulas endoteliales inhibe la apoptosis \u00abin vitro\u00bb de la leucemia linfocitica b.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La interleuquina 6 secretada por las celulas endoteliales inhibe la apoptosis \u00abin vitro\u00bb de la leucemia linfocitica b. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Moreno Cerro Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ernesto Roldan Santiago<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin gregorio Zapata gonzalez <\/li>\n<li>Jos\u00e9 Antonio Brieva romero (vocal)<\/li>\n<li>gumersindo Fontan casariego (vocal)<\/li>\n<li>augusto Silva gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Moreno Cerro Ana M. Son caracter\u00edsticas fundamentales de la leucemia linfoc\u00edtica cr\u00f3nica b (llc-b): 1) la acumulaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,450,156],"tags":[6521,14293,17597,6331,7334,175091],"class_list":["post-82269","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-inmunopatologia","category-patologia","tag-agustin-gregorio-zapata-gonzalez","tag-augusto-silva-gonzalez","tag-ernesto-roldan-santiago","tag-gumersindo-fontan-casariego","tag-jose-antonio-brieva-romero","tag-moreno-cerro-ana-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82269","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=82269"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82269\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=82269"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=82269"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=82269"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}