{"id":82273,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cuantificacion-de-la-proteina-p-53-y-her-2-neu-en-citosol-como-factores-pronostico-en-el-carcinoma-epitelial-de-ovario\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"cuantificacion-de-la-proteina-p-53-y-her-2-neu-en-citosol-como-factores-pronostico-en-el-carcinoma-epitelial-de-ovario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cuantificacion-de-la-proteina-p-53-y-her-2-neu-en-citosol-como-factores-pronostico-en-el-carcinoma-epitelial-de-ovario\/","title":{"rendered":"Cuantificacion de la proteina p-53 y her -2 \/ neu en citosol como factores pronostico en el carcinoma epitelial de ovario."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Rodriguez Rabanal <\/strong><\/h2>\n<p>La sobreexpresi\u00f3n de las prote\u00ednas p53 y p185 ocurre en diferentes c\u00e1nceres humanos y se relaciona con un peor pron\u00f3stico en alguno de ellos como en el caso del c\u00e1ncer de mama y colon. En este trabajo se estudia la concentraci\u00f3n de las prote\u00ednas p53 y p185 (en citosol mediante inmunoan\u00e1lisis por luminiscencia (lia) y elisa respectivamente) en el carcinoma epitelial de ovario, en la patolog\u00eda ov\u00e1rica benigna y en los ovarios normales y se correlaciona con los factores pron\u00f3stico cl\u00e1sicos en el c\u00e1ncer epitelial de ovario; tambi\u00e9n se eval\u00faa la importancia pron\u00f3stica de los genes p53 y her-2\/neu en cuanto a la supervivencia de las pacientes y el tiempo libre de enfermedad.  el estudio se realiz\u00f3 en 150 pacientes, de las cuales 74 fueron carcinomas epiteliales de ovario, 58 tumorazones benignas ov\u00e1ricas y 32 ovarios normales. La sobreexpresi\u00f3n de las prote\u00ednas p53 y p185 se observ\u00f3 de modo significativamente mayor en los carcinomas que en los ovarios no neopl\u00e1sicos (p=0.000). al relacionar la sobreexpresi\u00f3n de p53 mediante lia y los factores pron\u00f3stico cl\u00e1sicos en el c\u00e1ncer epitelial de ovariose encontr\u00f3 asociaci\u00f3n con el tipo histol\u00f3gico de c\u00e9lulas claras (p=0.025) y asociaci\u00f3n inversa con la afectaci\u00f3n de las cadenas linfoganglionares, siendo mayor la concentraci\u00f3n de p53 cuando no existi\u00f3 afectaci\u00f3n ganglionar (p=0.003). No se encontr\u00f3 asociaci\u00f3n con el resto de los factores pron\u00f3stico. Se asoci\u00f3 la sobreexpresi\u00f3n de la prote\u00edna p185 mediante elisa y el ca 125&gt;35 u\/ml (p=0.041) y se relacion\u00f3 inversamente con el grado de diferenciaci\u00f3n tumoral (p=0.0324), siendo mayor la concentraci\u00f3n de p185 en los tumores bien diferenciados. No se asoci\u00f3 con el resto de los factores pron\u00f3stico. No hubo relaci\u00f3n entre la sobreexpresi\u00f3n de las prote\u00ednas p53 y p185 y la supervivencia libre de enfermedad a los 5 a\u00f1os y aunque las diferencias no fueron significativas, dicha supervivencia fue<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cuantificacion de la proteina p-53 y her -2 \/ neu en citosol como factores pronostico en el carcinoma epitelial de ovario.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cuantificacion de la proteina p-53 y her -2 \/ neu en citosol como factores pronostico en el carcinoma epitelial de ovario. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Rodriguez Rabanal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Escudero Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: juliana Fari\u00f1a gonzalez <\/li>\n<li>Juan  ignacio \u00e1lvarez de los heros (vocal)<\/li>\n<li>Antonio Hernandez alcantara (vocal)<\/li>\n<li>enrique Iglesias goy (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Rodriguez Rabanal La sobreexpresi\u00f3n de las prote\u00ednas p53 y p185 ocurre en diferentes c\u00e1nceres humanos y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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