{"id":82277,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/linfoma-b-de-celulas-grandes-difuso-relacion-entre-proteinas-reguladoras-del-ciclo-celular-y-el-curso-clinico\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"linfoma-b-de-celulas-grandes-difuso-relacion-entre-proteinas-reguladoras-del-ciclo-celular-y-el-curso-clinico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/linfoma-b-de-celulas-grandes-difuso-relacion-entre-proteinas-reguladoras-del-ciclo-celular-y-el-curso-clinico\/","title":{"rendered":"Linfoma b de celulas grandes difuso. relacion entre proteinas reguladoras del ciclo celular y el curso clinico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sanchez Diaz M. Esther <\/strong><\/h2>\n<p>Los linfomas b de c\u00e9lulas grandes difusos (lbcgd) suponen un reto en numerosos campos de la investigaci\u00f3n y de la pr\u00e1ctica cl\u00ednica debido a su elevada frecuencia y gran variabilidad en cuanto a la presentaci\u00f3n cl\u00ednica, histoplog\u00eda, inmunohistoqu\u00edmica, gen\u00e9tica y respuesta al tratamiento. Por todo ello es necesario el estudio de factores que hagan posible predecir el curso cl\u00ednico en cada paciente para as\u00ed establecer terapias adecuadas en cada caso.  se han estudiado 141 casos de lbcgd realizando an\u00e1lisis cl\u00ednicos, morfol\u00f3gico e inmunohistoqu\u00edmico con posterior an\u00e1lisis estad\u00edstico.  las variables cl\u00ednicas estudiadas son las inclu\u00eddas en el ndice pron\u00f3stico internacional (ipi). Por otro lado se realizaron an\u00e1lisis en funci\u00f3n del origen tumor (ganglionar o extraganglionar) as\u00ed como de distintas entidades anatomocl\u00ednicas (lbcgd sobre linfoma folicular, lbcgd sobre linfoma malt, lbcgd mediast\u00ednico, lb \u00abburkitt-like\u00bb). las prote\u00ednas estudiadas son: bc12, ki67, rb, p53, p21 y mdm2.  los datos relevantes que se desprenden del an\u00e1lisis multivariante son:  * los factores influyentes en alcanzar la remisi\u00f3n completa tras tratamiento fueron los inclu\u00eddos en el ipi.  * la expresi\u00f3n de la prote\u00edna bc12 fue el \u00fanico factor relevante en la duraci\u00f3n de la supervivencia libre de enfermedad. siendo ambos inversamente proporcionales.  * se observ\u00f3 mayor supervivencia global en los casos con valores bajos del ipi y de mdm2 as\u00ed como niveles de expresi\u00f3n de ki67&lt;20% y de rb&gt;80%.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Linfoma b de celulas grandes difuso. relacion entre proteinas reguladoras del ciclo celular y el curso clinico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Linfoma b de celulas grandes difuso. relacion entre proteinas reguladoras del ciclo celular y el curso clinico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sanchez Diaz M. Esther <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Piris Pinilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: juli\u00e1n Sanz esponera <\/li>\n<li>horacio Oliva aldamiz (vocal)<\/li>\n<li>carmen Bellas men\u00e9ndez (vocal)<\/li>\n<li>Carlos Montalban sanz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sanchez Diaz M. Esther Los linfomas b de c\u00e9lulas grandes difusos (lbcgd) suponen un reto en numerosos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,52,156],"tags":[15428,15189,2941,6533,30250,175103],"class_list":["post-82277","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-histopatologia","category-patologia","tag-carlos-montalban-sanz","tag-carmen-bellas-menendez","tag-horacio-oliva-aldamiz","tag-julian-sanz-esponera","tag-miguel-angel-piris-pinilla","tag-sanchez-diaz-m-esther"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=82277"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82277\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=82277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=82277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=82277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}