{"id":82420,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-macrofagos-en-el-desarrollo-de-las-metastasis-hepaticas-del-cancer-de-colon-estudio-experimental-en-ratas\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"papel-de-los-macrofagos-en-el-desarrollo-de-las-metastasis-hepaticas-del-cancer-de-colon-estudio-experimental-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-los-macrofagos-en-el-desarrollo-de-las-metastasis-hepaticas-del-cancer-de-colon-estudio-experimental-en-ratas\/","title":{"rendered":"Papel de los macrofagos en el desarrollo de las metastasis hepaticas del cancer de colon. estudio experimental en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Gonzalez Bayon <\/strong><\/h2>\n<p>Los tumores de colon liberan c\u00e9lulas malignas al torrente circulatorio, las cuales son transportadas hasta el h\u00edgado por medio del sistema portal. Al llegar al h\u00edgado, las c\u00e9lulas tumorales encuentran un lecho vascular especial, ya que los sinusoides hep\u00e1ticos est\u00e1n tapizados por c\u00e9lulas kupffer y c\u00e9lulas endoteliales. Las c\u00e9lulas kupffer son macr\u00f3fagos hep\u00e1ticos capaces, entre otras funciones, de eliminar c\u00e9lulas tumorales. Por lo tanto, constituyen un potencial \u00absistema de vigilancia antitumoral\u00bb capaces de detectar, detener y eliminar c\u00e9lulas malignas, asi como de inducir la respuesta inmunol\u00f3gica del hu\u00e9sped y participar en ella. Adem\u00e1s, las c\u00e9lulas kupffer podr\u00edan ser estimuladas por 5 fluorouracilo y levamisol, para disminuir la recidiva tumoral.  para profundizar en el papel de los macr\u00f3fagos hep\u00e1ticos en el desarrollo de las met\u00e1stasis hep\u00e1ticas hemos realizado estudios experimentales \u00abin vivo\u00bb e \u00abin vitro\u00bb en ratas utilizando l\u00edneas celulares tumorales sing\u00e9nicas, derivadas de carcinoma de colon. Primero estudiamos las subpoblaciones de macr\u00f3fagos hep\u00e1ticos en la respuesta celular del hu\u00e9sped a las met\u00e1stasis hemat\u00f3genas del c\u00e1ncer de colon. Despu\u00e9s estudiamos el efecto de eliminar los macr\u00f3fagos hep\u00e1ticos sobre el desarrollo de las met\u00e1stasis y sobre la respuesta celular del hu\u00e9sped. Por \u00faltimo realizamos ensayos de citotoxicidad espontanea de las c\u00e9lulas kupffer frente a las c\u00e9lulas tumorales sing\u00e9nicas, y citotoxicidad de las c\u00e9lulas kupffer despu\u00e9s de incubaci\u00f3n con 5 fluorouracilo y levamisol frente a las c\u00e9lulas tumorales.  los resultados sugieren que las c\u00e9lulas kupffer detectan, detienen y eliminan las c\u00e9lulas tumorales del c\u00e1ncer de colon. Que inducen la respuesta celular del hu\u00e9sped frente a las met\u00e1stasis hep\u00e1ticas reclutando macr\u00f3fagos j\u00f3venes, los cuales juegan un papel importante en los estadios iniciales del desarrollo de las met\u00e1stasis. Y que l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los macrofagos en el desarrollo de las metastasis hepaticas del cancer de colon. estudio experimental en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los macrofagos en el desarrollo de las metastasis hepaticas del cancer de colon. estudio experimental en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Gonzalez Bayon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garcia Sabrido Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Balibrea  cantero <\/li>\n<li>Luis Fernando Carballo alvarez (vocal)<\/li>\n<li>ram\u00f3n Trullenque peris (vocal)<\/li>\n<li>daniel Casanova rituerto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Gonzalez Bayon Los tumores de colon liberan c\u00e9lulas malignas al torrente circulatorio, las cuales son transportadas 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