{"id":82512,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genotipos-del-virus-de-la-hepatitis-c-en-la-region-de-murcia\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"genotipos-del-virus-de-la-hepatitis-c-en-la-region-de-murcia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/genotipos-del-virus-de-la-hepatitis-c-en-la-region-de-murcia\/","title":{"rendered":"Genotipos del virus de la hepatitis c en la region de murcia."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ortiz Romero M. Mar <\/strong><\/h2>\n<p>Desde el descubrimiento del virus de la hepatitis c (vhc), se han desarrollado multiples t\u00e9cnicas serol\u00f3gicas y moleculares para su diagn\u00f3stico. En la regi\u00f3n de murcia no existen estudios que analicen la eficiencia del diagn\u00f3stico de la hepatitis c en poblaciones con riesgo a presentarla, tampoco existen estudios que analicen la distribuci\u00f3n de los genotipos del virus en dicha poblaci\u00f3n, ni la incidencia de los mismos en la biopsia hep\u00e1tica. Por este motivo, se plante\u00f3 como objetivos: estudiar la relaci\u00f3n entre la presencia de anticuerpos frente al vhc mediante elisa de segunda generaci\u00f3n (elisa ii) y la presencia de rnaviral por pcr en poblaci\u00f3n de alto riesgo de hepatitis c; determinar la epidemiolog\u00eda de esta poblaci\u00f3n; el mapa de genotipos en la poblaci\u00f3n infectada y su relaci\u00f3n con la v\u00eda adquisici\u00f3n; determinar la relaci\u00f3n entre el genotipo la cuatificaci\u00f3n viral y la v\u00eda de adquisici\u00f3n; y por \u00faltimo, relacionar las lesiones histol\u00f3gicas hep\u00e1ticas, el genotipo del vhc y los niveles de viremia. Por este motivo, se seleccion\u00f3 278 pacientes a los que se les determin\u00f3 por elisa anticuerpos frente a vhc, vhb y vih, en el caso de vhc fu\u00e9 un elisa ii. Los pacientes con anticuerpos para vhc, se les determin\u00f3 rna viral por pcr mediante el kit amplicor, si eran positivos para viremia se les cuantific\u00f3 rna por el kit amplicor monitor, para posteriormente determinar el genotipo por la t\u00e9cnica inno-lipa. Los resultados mostraron una asociaci\u00f3n entre la t\u00e9cnica de elisa y pcr (p&lt;0.00001) encontrando el 80.2% de los pacientes conviremia y anticuerpos frente a vhc, mientras que el 10.1% solo presentaron anticuerpos y ning\u00fan paciente con elisa negativo present\u00f3 pcr positiva. En la poblaci\u00f3n predomin\u00f3 la adquisici\u00f3n del virus por ser usuarios a drogas v\u00eda parenteral (advp) (44.2%), seguido por casos espor\u00e1dicos (37.8%) y transfusiones (17.9%). El 44.2% present\u00f3 serolog\u00eda de hepatitis b positiva y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Genotipos del virus de la hepatitis c en la region de murcia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Genotipos del virus de la hepatitis c en la region de murcia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ortiz Romero M. Mar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Segovia Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda no Gacto fern\u00e1ndez <\/li>\n<li>vicente Olaso peiro (vocal)<\/li>\n<li>tomas Rodriguez gonzalez (vocal)<\/li>\n<li>Juan  Luis Mu\u00f1oz bellido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ortiz Romero M. Mar Desde el descubrimiento del virus de la hepatitis c (vhc), se han desarrollado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,35,9,597,8235,280],"tags":[25841,3373,24953,175410,67047,102924],"class_list":["post-82512","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-microbiologia-clinica","category-murcia","category-virologia","tag-juan-luis-munoz-bellido","tag-manuel-segovia-hernandez","tag-maria-no-gacto-fernandez","tag-ortiz-romero-m-mar","tag-tomas-rodriguez-gonzalez","tag-vicente-olaso-peiro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=82512"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82512\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=82512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=82512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=82512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}