{"id":82663,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-funcional-del-sistema-inmune-de-losratones-ts65dn\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"evaluacion-funcional-del-sistema-inmune-de-losratones-ts65dn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/evaluacion-funcional-del-sistema-inmune-de-losratones-ts65dn\/","title":{"rendered":"Evaluacion funcional del sistema inmune de losratones ts65dn."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Paz Miguel Jes\u00fas Enrique <\/strong><\/h2>\n<p>El s\u00edndrome de down o trisom\u00eda 21 es el transtorno cromos\u00f3mico m\u00e1s frecuente entre los seres humanos que nacen a t\u00e9rmino. A lo largo de su vida las personas con sd presentan con relativa frecuencia una elevada incidencia de infecciones bacterianas y v\u00edricas. todo ello hace pensar que los transtornos de la inmunidad pueden contribuir al cuadro cl\u00ednico del sd y estar relacionado con las alteraciones del metabolismo oxidativo.  los ratones ts65dn presentan una trisom\u00eda restringida al segmento que dentro del cromosoma 16 murino, es hom\u00f3logo al 21 humano. Nos planteamos validar este modelo en relaci\u00f3n a las alteraciones inmunol\u00f3gicas y estudiar los diferentes aspectos de la respuesta inmunol\u00f3gica.  el desarrollo experimental se realiz\u00f3 en dos partes. En la primera parte se analiz\u00f3 globalmente la respuesta inmunitaria. As\u00ed los ratones ts65dn presentan las siguientes caracter\u00edsticas: (i) disminuci\u00f3n de los niveles de iga y aumento de igg en el suero, (ii) disminuci\u00f3n de las c\u00e9lulas cd4+ en sangra, (iii) niveles elevados de interferon gamma, (iv) mayor expresi\u00f3n de mol\u00e9culas del mhc ii y (v) presentaci\u00f3n m\u00e1s eficaz de los ant\u00edgenos.  en la segunda parte se analiz\u00f3 el timo de los ts65dn, siendo lo m\u00e1s relevante: el incremento de las c\u00e9lulas apopt\u00f3ticas, menor n\u00famero de c\u00e9lulas cd4+cd8+, mayor sensibilidad a la apoptosis, niveles superiores de per\u00f3xidos y reversi\u00f3n de la apoptosis con antioxidantes. En resumen, se ha constatado la implicaci\u00f3n de los radicales del ox\u00edgeno en el proceso.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluacion funcional del sistema inmune de losratones ts65dn.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluacion funcional del sistema inmune de losratones ts65dn. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Paz Miguel Jes\u00fas Enrique <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Leyva Cobi\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Luisa Toribio garcia <\/li>\n<li> Cuadrado del barrio Emilio (vocal)<\/li>\n<li>reyes Flores herraez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paz Miguel Jes\u00fas Enrique El s\u00edndrome de down o trisom\u00eda 21 es el transtorno cromos\u00f3mico m\u00e1s frecuente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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