{"id":82665,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-bcl-xk-en-la-diferenciacion-mieloide-y-participacion-de-hrk-en-el-control-de-la-apoptosis-en-progenitores-hematopoyeticos\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"regulacion-de-bcl-xk-en-la-diferenciacion-mieloide-y-participacion-de-hrk-en-el-control-de-la-apoptosis-en-progenitores-hematopoyeticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-de-bcl-xk-en-la-diferenciacion-mieloide-y-participacion-de-hrk-en-el-control-de-la-apoptosis-en-progenitores-hematopoyeticos\/","title":{"rendered":"Regulacion de bcl-xk en la diferenciacion mieloide y participacion de hrk en el control de la apoptosis en progenitores hematopoyeticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Sanz Ibayondo <\/strong><\/h2>\n<p>La apoptosis o muerte celular programada es un proceso evolutivamente conservado y gen\u00e9ticamente regulado, que lleva a la eliminaci\u00f3n autocontrolada de la c\u00e9lula, sin inducir respuesta inflamatoria. se caracteriza por una condensaci\u00f3n de la cromatina nuclear, y del citoplasma, una compactaci\u00f3n de los org\u00e1nulos celulares con la consiguiente reducci\u00f3n del tama\u00f1o de la c\u00e9lula y la formaci\u00f3n de prolongaciones citopl\u00e1smicas que terminar\u00e1n estrangul\u00e1ndose y formar\u00e1n los cuerpos apopt\u00f3ticos que ser\u00e1n fagocitados por macr\u00f3fagos.  puede iniciarse por una gran variedad de se\u00f1ales extracelulares como la deprivaci\u00f3n de factor de crecimiento, una alteraci\u00f3n producida en el adn o distintos tratamientos como alucocorticoi des o quimioterapia. Estas se\u00f1ales de muerte llevan a la activaci\u00f3n de proteasas, conocidas como caspasas, responsables de los cambios morfol\u00f3gicos caracter\u00edsticos de la apoptosis, que provocar\u00e1n finalmente la muerte de la c\u00e9lula. El proceso est\u00e1 regulado por genes de la familia de bc1-2. En el sistema hematopoy\u00e9tico, la muerte celular por apoptosis mantiene la homeostasis tisular, eliminando c\u00e9lulas que se han desarrollado de manera defectuosa o aqu\u00e9llas que han cumplido su programa de diferenciaci\u00f3n. Los genes implicados en apoptosis m\u00e1s relevantes en el sistema hematopoy\u00e9tico son bcl-2 y bcl-xl como lo han demostrado los estudios de los ratones \u00abknockout\u00bb de estos genes. El rat\u00f3n deficiente en bcl-2 muere a las pocas semanas de vida mostrando inestabilidad en el comportamiento linfoide y el rat\u00f3n deficiente en bcl-xl muere intrauterinamente y se observa apoptosis masiva en el sistema hematopoy\u00e9tico en desarrollo.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de bcl-xk en la diferenciacion mieloide y participacion de hrk en el control de la apoptosis en progenitores hematopoyeticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de bcl-xk en la diferenciacion mieloide y participacion de hrk en el control de la apoptosis en progenitores hematopoyeticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Sanz Ibayondo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Fernandez Luna<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lacal san Juan  Juan  Carlos <\/li>\n<li>angel Corbi lopez (vocal)<\/li>\n<li>felipe Luis Prosper cardoso (vocal)<\/li>\n<li>augusto Silva gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Sanz Ibayondo La apoptosis o muerte celular programada es un proceso evolutivamente conservado y gen\u00e9ticamente regulado, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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