{"id":82702,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelos-de-prediccion-de-la-fijacion-del-porpofol-a-proteinas-sericas-en-diferentes-grupos-de-poblacion-con-alteraciones-lipoproteicas\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"modelos-de-prediccion-de-la-fijacion-del-porpofol-a-proteinas-sericas-en-diferentes-grupos-de-poblacion-con-alteraciones-lipoproteicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelos-de-prediccion-de-la-fijacion-del-porpofol-a-proteinas-sericas-en-diferentes-grupos-de-poblacion-con-alteraciones-lipoproteicas\/","title":{"rendered":"Modelos de prediccion de la fijacion del porpofol a proteinas sericas en diferentes grupos de poblacion con alteraciones lipoproteicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fuente Lecanda Leire De La <\/strong><\/h2>\n<p>El propofol es un agente anest\u00e9sico intravenoso, entre cuyas principales caracter\u00edsticas se encuentra la amplia variabilidad interindividual obtenida en el efecto tras la administraci\u00f3n de una misma dosis. Una de las posibles causas de esta variabilidad, puede radicar en su fijaci\u00f3n a prote\u00ednas s\u00e9ricas. Se ha demostrado la uni\u00f3n de este f\u00e1rmaco a la alb\u00famina y a la aga. Sin embargo, estudios realizados sobre suero de pacientes con patolog\u00edas que cursaban con alteraciones en las cifras de estas prote\u00ednas no obtuvieron modificaciones en la fijaci\u00f3n del propofol. Partiendo de estos antecedentes, se plantea la hop\u00f3tesis de la presente tesis doctoral: se estudia la fijaci\u00f3n a lipoprote\u00ednas aisladas, su constante de afinidad para cada lipoprote\u00edna y su modelo de uni\u00f3n. Asimismo, se estudian posibles interacciones con otros f\u00e1rmacos de elevada fijaci\u00f3n a lipoprote\u00ednas s\u00e9ricas: ciclosporina, propranolol, nicardipino, probucol, anfotericina e imipramina. A continuaci\u00f3n, se estudia la fijaci\u00f3n de este agente anest\u00e9sico en suero de voluntarios sanos, diab\u00e9ticos tipo i y tipo ii, hipo e hipertiroideos y alcoh\u00f3licos. Para cada grupo de poblaci\u00f3n, se elabora un modelo, a partir del cual poder predecir la fijaci\u00f3n del propofol. De esta forma, parece que, sustituyendo las concentraciones de lipoprote\u00ednas s\u00e9ricas o de colesterol y triglic\u00e9ridos en el modelo, se puede llegar a conocer la fijaci\u00f3n del propofol en cada individuo, con las patolog\u00edas estudiadas, que vaya a ser anestesiado con este f\u00e1rmaco y contribuir a disminuir la variabilidad interindividual.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelos de prediccion de la fijacion del porpofol a proteinas sericas en diferentes grupos de poblacion con alteraciones lipoproteicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelos de prediccion de la fijacion del porpofol a proteinas sericas en diferentes grupos de poblacion con alteraciones lipoproteicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fuente Lecanda Leire De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Suarez Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosario Calvo duo <\/li>\n<li>raimundo Carlos garcia (vocal)<\/li>\n<li> Rodriguez sasian Jos\u00e9 Miguel (vocal)<\/li>\n<li>sergio Erill saez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fuente Lecanda Leire De La El propofol es un agente anest\u00e9sico intravenoso, entre cuyas principales caracter\u00edsticas se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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