{"id":82726,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-embriologico-de-la-atresia-de-esofago-inducida-por-adriamicina-en-la-rata\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"estudio-embriologico-de-la-atresia-de-esofago-inducida-por-adriamicina-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-embriologico-de-la-atresia-de-esofago-inducida-por-adriamicina-en-la-rata\/","title":{"rendered":"Estudio embriologico de la atresia de esofago inducida por adriamicina en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Kathrine Possogel Anne <\/strong><\/h2>\n<p>Tanto la atresia esof\u00e1gica (ae) con o sin f\u00edstula traqueoesof\u00e1gica como sus anomal\u00edas asociadas del sistema musculoesquel\u00e9tico, urogenital y nervioso (conocido como s\u00edndrome de vater), son malformaciones cong\u00e9nitas graves del humano. Hasta hoy gran parte de la embriolog\u00eda, patogenia y morfog\u00e9nesis de esta malformaci\u00f3n quedan sin aclaraci\u00f3n. Un modelo animal hizo posible reproducir exactamente esta malformaci\u00f3n en fetos de rata. La inyecci\u00f3n de adriamicina a ratas pre\u00f1adas en los d\u00edas 6 a 9 de la gestaci\u00f3n produce defectos muy semejantes a los observados en humanos en m\u00e1s de la mitad de los animales. en este trabajo se estudiaron, mediante innumerables cortes hirtol\u00f3gicos horizontales, embriones de 12, 12.5 y 13 d\u00edas de gestaci\u00f3n, cuyas madres recibieron suero salino (controles) o adriamicina (experimentales).  es\u00f3fago y tr\u00e1quea derivan del intestino primitivo anterior, un tubo \u00fanico que se separa en ambas estructuras antes del d\u00eda 35 de la gestaci\u00f3n en embriones humanos. Primero determinamos que la fecha de la separaci\u00f3n normal en es\u00f3fago y tr\u00e1quea es el d\u00eda 12 en la rata, lo que corresponde a los d\u00edas 29-32 del humano.  mientras los embriones controles no ten\u00edan malformaciones, 40 a 62% de los tratados con adriamicina presentaron anomal\u00edas traqueoesof\u00e1gicas. la apariencia del defecto variaba. embriones de 12 y 12.5 d\u00edas mostraron un defecto semejante a una \u00abesofagotr\u00e1quea\u00bb. La ae t\u00edpica con o sin f\u00edstula s\u00f3lo se observ\u00f3 en embriones de 12.5 y 13 d\u00edas con un retraso de medio d\u00eda con respecto a la fecha del desarrollo normal. La \u00abesofagotr\u00e1quea\u00bb se explicar\u00eda por una p\u00e9rdida de material celular de la parte dorsal (esof\u00e1gica) y el desequilibrio del crecimiento con un intento de reparaci\u00f3n de la separaci\u00f3n fracasada.  aparte de los defectos traqueoesof\u00e1gicos se observaron en embriones tratados con adriamicina defectos de la notocorda. La notocorda funciona como eje primitivo d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio embriologico de la atresia de esofago inducida por adriamicina en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio embriologico de la atresia de esofago inducida por adriamicina en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Kathrine Possogel Anne <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Tovar Larrucea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Hern\u00e1ndez rodr\u00edguez <\/li>\n<li>Luis Morales fochs (vocal)<\/li>\n<li>Manuel Nistal m.-serrano (vocal)<\/li>\n<li>Emilio Blesa s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Kathrine Possogel Anne Tanto la atresia esof\u00e1gica (ae) con o sin f\u00edstula traqueoesof\u00e1gica como sus anomal\u00edas asociadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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