{"id":82727,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-metabolicas-neurona-glia-durante-la-isquemia-cerebral-focal-detectadas-por-resonancia-magnetica-de-carbono-13\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"interacciones-metabolicas-neurona-glia-durante-la-isquemia-cerebral-focal-detectadas-por-resonancia-magnetica-de-carbono-13","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interacciones-metabolicas-neurona-glia-durante-la-isquemia-cerebral-focal-detectadas-por-resonancia-magnetica-de-carbono-13\/","title":{"rendered":"Interacciones metabolicas neurona-glia durante la isquemia cerebral focal detectadas por resonancia magnetica de carbono-13."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Mar\u00eda Pascual Garvi <\/strong><\/h2>\n<p>Se han estudiado cuantitativamente los efectos de la isquemia cerebral focal (icf) sobre las interacciones metab\u00f3licas entre neuronas y c\u00e9lulas gliales mediante la aplicaci\u00f3n de la espectroscop\u00eda de 13c rm y modelos matem\u00e1ticos del metabolismo. Se indujo un infarto cortical en el hemisferio cerebral derecho de ratas adultas long-evans, mediante la oclusi\u00f3n permanente de la arteria cerebral media derecha y la oclusi\u00f3n transitoria de ambas arterias car\u00f3tidas durante 90 minutos. Los animales se infundieron a trav\u00e9s de la arteria car\u00f3tida derecha con (1,2-13c2) acetato \u00f3 con una combinaci\u00f3n de (2-13c,2-2h3) acetato y (1-13c) glucosa, bien inmediatamente despu\u00e9s de la reperfusi\u00f3n de la circulaci\u00f3n carot\u00eddea (grupo 1 hora), o 23 horas m\u00e1s tarde (grupo 24 horas). Se prepararon extractos de ambos hemisferios cerebrales y se analizaron por separado mediante 13c rm y modelizaci\u00f3n metab\u00f3lica asistida por ordenador.  la icf redujo el metabolismo oxidativo cerebral de glucosa de manera tiempo-dependiente. La reducci\u00f3n en la oxidaci\u00f3n de glucosa se compens\u00f3 con un incremento del metabolismo glial de glutamato y gaba en el hemisferio ipsilateral de ambos grupos. se observ\u00f3 un incremento en el metabolismo oxidativo de glutamina en las neuronas de ambos hemisferios en el grupo de veinticuatro horas. En este grupo se observ\u00f3 en el hemisferio ipsilateral un incremento importante en la actividad del reciclaje cerebral de piruvato en el compartimento neuronal. Tomados en conjunto, estos resultados son consistentes con la utilizaci\u00f3n de glutamato y gab \u00f3 glutamina como sustratos cerebrales alternativos a glucosa por astrocitos \u00f3 neuronas durante la isquemia cerebral focal. Se propone un papel neuroprotector frente a la excitotoxicidad glutamat\u00e9rgica del ciclo glutamato-glutamina-gaba y un papel neuroprotector del reciclaje neuronal de piruvato frente al da\u00f1o de reperfusi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones metabolicas neurona-glia durante la isquemia cerebral focal detectadas por resonancia magnetica de carbono-13.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones metabolicas neurona-glia durante la isquemia cerebral focal detectadas por resonancia magnetica de carbono-13. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Mar\u00eda Pascual Garvi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Roda Frade Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez montes <\/li>\n<li>paloma Ballesteros Garc\u00eda (vocal)<\/li>\n<li>ramiro Diaz lobato (vocal)<\/li>\n<li>Rafael Garcia sola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Mar\u00eda Pascual Garvi Se han estudiado cuantitativamente los efectos de la isquemia cerebral focal (icf) sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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