{"id":82739,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-estructurales-y-funcionales-del-genoma-del-virus-molluscum-contagiosum\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"analisis-estructurales-y-funcionales-del-genoma-del-virus-molluscum-contagiosum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-estructurales-y-funcionales-del-genoma-del-virus-molluscum-contagiosum\/","title":{"rendered":"Analisis estructurales y funcionales del genoma del virus molluscum contagiosum"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Moratilla Martinez <\/strong><\/h2>\n<p>En este trabajo se determina y analiza la secuencia de un gran n\u00famero de fragmentos del genoma del pxvirus humano molluscum contagiosum (mcv), construy\u00e9ndose el mapa g\u00e9nico viral y estudi\u00e1ndose la variabilidad gen\u00e9tica existente entre distintos aislados de mcv. Asimismo, se analiza la expresi\u00f3n de presuntos genes de este poxvirus con distintos patrones de expresi\u00f3n temporal. Finalmente, se caracteriza funcionalmente una prote\u00edna de mcv que presenta homolog\u00eda con las quimioquinas humanas.  los datos presentados demuestran que el genoma de mcv contiene una regi\u00f3n central cuya organizaci\u00f3n gen\u00f3mica es muy similar a la observada en las regiones centrales de los genomas de orthopoxvirus (opv). Esta conservaci\u00f3n se pierde en los extremos del genoma, que incluyen genes espec\u00edficos de mcv, aparentemente implicados en la patog\u00e9nesis t\u00edpica de este poxvirus. La expresi\u00f3n de determinados genes virales ha sido demostrada in vivo. los resultados derivados del an\u00e1lisis de transcritos, as\u00ed como los deducidos de los datos de secuencia, sugieren que la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica de mcv es an\u00e1loga a la de opv. por otra parte, se pone de manifiesto la existencia de elementos repetidos dentro de la regi\u00f3n central del genoma, cuyo n\u00famero variable confiere un tipo de heterogeneidad gen\u00e9tica no descrita anteriormente. Finalmente, se ha estudiado el efecto del hom\u00f3logo viral de quimioquinas-cc sobre la quimiotaxis de leucocitos, demostr\u00e1ndose que la prote\u00edna de mcv es un antagonista espec\u00edfico de quimioquinas-cc humanas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis estructurales y funcionales del genoma del virus molluscum contagiosum<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis estructurales y funcionales del genoma del virus molluscum contagiosum <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Moratilla Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Martin Gallardo Mar\u00eda  Antonia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Arnaiz villena <\/li>\n<li>Rafael Blasco lozano (vocal)<\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<li>m. angeles Mu\u00f1oz fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Moratilla Martinez En este trabajo se determina y analiza la secuencia de un gran n\u00famero de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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