{"id":82815,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-de-las-muteciones-del-gen-del-receptor-de-androgenos-humano-en-cancer-de-prostata\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"valor-de-las-muteciones-del-gen-del-receptor-de-androgenos-humano-en-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-de-las-muteciones-del-gen-del-receptor-de-androgenos-humano-en-cancer-de-prostata\/","title":{"rendered":"Valor de las muteciones del gen del receptor de androgenos humano en cancer de prostata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Garcia Foncillas Lopez <\/strong><\/h2>\n<p>El c\u00e1ncer de pr\u00f3stata constituye la enfermedad neopl\u00e1sica m\u00e1s frecuente en varones y es responsable del 10% de las muertes por c\u00e1ncer en esta poblaci\u00f3n. El pron\u00f3stico de este proceso se encuentra fundamentalmente en relaci\u00f3n con el estadiaje cl\u00ednico-patol\u00f3gico, grado histol\u00f3gico, niveles s\u00e9ricos de psa y grupo \u00e9tnico junto con algunas potenciales variables moleculares como la expresi\u00f3n de p53, la ploid\u00eda y el estado del receptor de andr\u00f3genos cuyo papel pron\u00f3stico no est\u00e1 claro.  en este trabajo nos planteamos evaluar en un grupo bien caracterizado cl\u00ednicamente de 50 pacientes de c\u00e1ncer de pr\u00f3stata con estadios pt2a a pt3b la incidencia de mutaciones del gen del receptor de andr\u00f3genos (har) determinando las posibles regiones gen\u00f3micas con mayor frecuencia de alteraci\u00f3n en su secuencia as\u00ed como la relaci\u00f3n entre las mutaciones del gen, la supervivencia de los pacientes y la predicci\u00f3n de recidiva de su enfermedad de base.  se ha realizado la extracci\u00f3n del adn a partir de muestra de tumor viable anatomopatol\u00f3gicamente comprobada amplific\u00e1ndose posteriormente los ocho exones del gen har y secuenci\u00e1ndose en un abi-377. Los resultados han sido analizados mediante comparaci\u00f3n con genbank. la proliferaci\u00f3n se ha estudiado mediante citometr\u00eda de flujo y marcaje con ioduro de propidio.  la incidencia de mutaciones encontradas se cifra en un 14% correspondiendo todas ellas a mutaciones puntuales. No existe ninguna relaci\u00f3n estad\u00edstica con el estadio patol\u00f3gico, grado de infiltraci\u00f3n linf\u00e1tica, gleason, proliferaci\u00f3n ni niveles de psa s\u00e9rico. Las alteraciones gen\u00f3micas que afectan de forma espec\u00edfica al dominio de uni\u00f3n a ligando se acompa\u00f1an de un incremento estad\u00edsticamente significativo en la probabilidad de recidiva as\u00ed como una disminuci\u00f3n tambi\u00e9n significativa de la supervivencia libre de enfermedad y de la supervivencia global.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor de las muteciones del gen del receptor de androgenos humano en cancer de prostata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor de las muteciones del gen del receptor de androgenos humano en cancer de prostata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Garcia Foncillas Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Brugarolas Masllorens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis angel Rioja sanz <\/li>\n<li> Berian polo Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li>Luis Montuenga badia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Garcia Foncillas Lopez El c\u00e1ncer de pr\u00f3stata constituye la enfermedad neopl\u00e1sica m\u00e1s frecuente en varones y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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