{"id":82822,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-farmaco-nutriente-efecto-de-lafluoxetina-en-la-absorcion-intestinal-del-5-metiltetrahidrofolato\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"interacciones-farmaco-nutriente-efecto-de-lafluoxetina-en-la-absorcion-intestinal-del-5-metiltetrahidrofolato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/interacciones-farmaco-nutriente-efecto-de-lafluoxetina-en-la-absorcion-intestinal-del-5-metiltetrahidrofolato\/","title":{"rendered":"Interacciones farmaco-nutriente: efecto de lafluoxetina en la absorcion intestinal del 5-metiltetrahidrofolato."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amparo Amilburu Perez <\/strong><\/h2>\n<p>Dentro de la fisiolog\u00eda y de la nutrici\u00f3n un campo que cobra cada vez m\u00e1s inter\u00e9s es el del estudio de interacciones entre f\u00e1rmacos y nutrientes.  el objeto del presente trabajo es estudiar el efecto de la fluoxetina (flx) sobre la absorci\u00f3n intestinal de 5-metiltetrahidrogolato (5-mtf), teniendo en cuenta:  a) la flx es uno de los f\u00e1rmacos m\u00e1s utilizados actualmente en el tratamiento de la depresi\u00f3n. Como es un f\u00e1rmaco de administraci\u00f3n oral, puede interferir con la digesti\u00f3n y absorci\u00f3n de nutrientes. Ya se ha observado que la flx inhibe la absorci\u00f3n de az\u00facares y de amino\u00e1cidos.  b) la deficiencia vitam\u00ednica m\u00e1s frecuente en los pa\u00edses desarrollados es la de folatos, y las consecuencias que puede acarrear son importantes.  para los objetivos concretos de este estudio se ha seguido el siguiente plan de trabajo:  1) en rata se ha medido la captaci\u00f3n de 5-mtf en anillos y ves\u00edculas del borde en cepillo (bbmv) tanto cuando el f\u00e1rmaco se pon\u00eda en contacto directo con la preparaci\u00f3n en estudio como cuando el f\u00e1rmaco se administraba previamente a los animales. En este caso se ha medido igualmente el efecto del f\u00e1rmaco sobre la concentraci\u00f3n s\u00e9rica y eritrocitaria de 5-mtf.  2) en c\u00e9lulas caco-2 se han medido captaci\u00f3n y flujos del compuesto vitam\u00ednico.  3) en biopsias humanas se ha estudiado el efecto sobre la captaci\u00f3n de 5-mtf.  los resultados obtenidos indican una acci\u00f3n de la flx sobre el transportador luminal de folatos lo suficientemente importante como para reducir la concentraci\u00f3n circulante y tisular de 5-mtf.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones farmaco-nutriente: efecto de lafluoxetina en la absorcion intestinal del 5-metiltetrahidrofolato.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones farmaco-nutriente: efecto de lafluoxetina en la absorcion intestinal del 5-metiltetrahidrofolato. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amparo Amilburu Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Larralde Berrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>Ana isabel Alcalde herrero (vocal)<\/li>\n<li>Santiago Santidrian alegre (vocal)<\/li>\n<li>florencio Marzo perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amparo Amilburu Perez Dentro de la fisiolog\u00eda y de la nutrici\u00f3n un campo que cobra cada vez [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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